After lesions within the differentiated central nervous system (CNS) of upper vertebrates, interrupted fibre tracts don’t regrow and elongate by greater than an preliminary sprout of roughly 1 mm. Transplantations of items of peripheral nerves into numerous elements of the CNS display the widespread functionality of CNS neurons to regenerate lesioned axons over lengthy distances in a peripheral nerve setting. CNS white matter, cultured oligodendrocytes (the myelin-producing cells of the CNS), and CNS myelin itself, are sturdy inhibitors of neuron progress in tradition, a property related to outlined myelin membrane proteins of relative molecular mass (Mr) 35,000 (NI-35) and 250,000 (NI-250).
Now we have now intracerebrally utilized the monoclonal antibody IN-1, which neutralizes the inhibitory impact of each these proteins, to younger rats by implanting antibody-producing tumours. In 2-6-week-old rats we made full transections of the cortico-spinal tract, a serious fibre tract of the spinal twine, the axons of which originate within the motor and sensory neocortex. Earlier research have proven an entire absence of cortico-spinal tract regeneration after the primary postnatal week in rats, and in grownup hamsters and cats. In IN-1-treated rats, large sprouting occurred on the lesion website, and high-quality axons and fascicles may very well be noticed as much as 7-11 mm caudal to the lesion inside 2-Three weeks.
In management rats, an identical sprouting response occurred, however the maximal distance of elongation not often exceeded 1 mm. These outcomes display the capability for CNS axons to regenerate and elongate inside differentiated CNS tissue after the neutralization of myelin-associated neurite progress inhibitors. The cytological and topographical distribution of S-100 and glial fibrillary acidic (GFA) proteins within the grownup rat mind has been in contrast utilizing the horseradish peroxidase-labelled antibody method.
Each proteins are current in astrocytes and buildings composed of astrocytic processes, specifically the glial limitans and the perivascular membranes, however the cytological localization varies between the 2 proteins. S-100 is discovered within the nucleus and cytoplasm whereas GFA protein is confined to the cytoplasm. Neither is present in neurons, however S-100 is current in some oligodendroglia, suggesting a common regulatory position in glia. Though GFA protein in current in each protoplasmic and fibrous astrocytes, it’s extra outstanding within the latter, confirming its affiliation with astrocytic filaments.
Macrophage heterogeneity within the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor kind 3.
Two monoclonal antibodies, designated MRC OX-41 and MRC OX-42, have been proven to label subsets of macrophages. Utilizing immunoperoxidase and immunofluorescence evaluation, tissue macrophages had been proven to be heterogeneous with respect to binding of MRC OX-41 and MRC OX-42 antibodies. Though each antibodies labelled subsets of macrophages, the antibodies additionally reacted with granulocytes and dendritic cells. The antigens acknowledged by these antibodies had been recognized by metabolic and cell floor labelling adopted by immunoprecipitation and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE).
MRC OX-41 acknowledged a floor protein of 110,000-120,000 MW, whereas MRC OX-42 immunoprecipitated three polypeptides with molecular weights of 160,000, 103,000 and 95,000. The Fab fragment of MRC OX-42 antibody inhibited complement-mediated rosette formation between sensitized erythrocytes and rat macrophages and granulocytes. Membrane molecules with comparable biochemical and useful properties to MRC OX-42 antigen have been recognized in mouse and man because the receptors for iC3b, and it’s possible that MRC OX-42 antibody acknowledges the rat homologue of the receptors in these different species.
In heterologous immune advanced glomerulonephritis glomerular deposition of immune complexes happens instantly after an injection with heterologous antibody directed towards antigen, derived from the comb border of the tubules. The injected antibody is believed to mix with circulating Fx1A antigen to type immune complexes which subsequently are deposited within the glomeruli. Nevertheless, perfusion of rat kidneys in absence of this antigen likewise resulted in immediate localization of immune complexes alongside the glomerular basement membrane.
Identification and preliminary characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand advanced.
Xenogeneic monoclonal antibodies had been ready to the murine interleukin 2 (IL-2)-dependent HT2 cell line. One rat IgM monoclonal antibody (7D4) was recognized that inhibited proliferation of the HT2 cells and of IL-2-dependent CTLL cells within the presence of crude rat IL-2 in addition to of purified human IL-2. The extent of inhibition was depending on each antibody and IL-2 focus. Cell distribution research utilizing a fluorescence-activated cell sorter confirmed that the antigen recognized by 7D4 is expressed at a excessive density on HT2 cells and on concanavalin A (Con A)-induced
 Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
 LDLRAD3 Antibody |
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| 1-CSB-PA007326 | Cusabio |
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Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IF, ELISA;IF:1/200-1/1000.ELISA:1/40000 |
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LDLRAD3 Antibody |
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| CSB-PA786511- | Cusabio | EUR 335 | |
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Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500 |
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LDLRAD3 Antibody |
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| CSB-PA786511-100ul | Cusabio | 100ul | EUR 316 |
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Description: A polyclonal antibody against LDLRAD3. Recognizes LDLRAD3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500 |
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LDLRAD3 Antibody |
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| 34765-100ul | SAB | 100ul | EUR 252 |
LDLRAD3 Antibody |
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| 34765-50ul | SAB | 50ul | EUR 187 |
LDLRAD3 Antibody |
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| 39887-100ul | SAB | 100ul | EUR 390 |
 LDLRAD3 antibody |
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| 70R-35512 | Fitzgerald | 100 ug | EUR 327 |
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Description: Purified Rabbit polyclonal LDLRAD3 antibody |
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LDLRAD3 antibody |
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| 70R-9224 | Fitzgerald | 50 ug | EUR 467 |
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Description: Affinity purified rabbit polyclonal LDLRAD3 antibody |
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LDLRAD3 antibody |
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| 70R-51775 | Fitzgerald | 100 ul | EUR 244 |
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Description: Purified Polyclonal LDLRAD3 antibody |
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 LDLRAD3 Polyclonal Antibody |
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| ES4839-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA |
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LDLRAD3 Polyclonal Antibody |
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| ES4839-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against LDLRAD3 from Human/Mouse. This antibody is tested and validated for IF, WB, ELISA |
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LDLRAD3 Polyclonal Antibody |
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| ABP53840-003ml | Abbkine | 0.03ml | EUR 158 |
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Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
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LDLRAD3 Polyclonal Antibody |
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| ABP53840-01ml | Abbkine | 0.1ml | EUR 289 |
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Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
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LDLRAD3 Polyclonal Antibody |
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| ABP53840-02ml | Abbkine | 0.2ml | EUR 414 |
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Description: A polyclonal antibody for detection of LDLRAD3 from Human, Mouse. This LDLRAD3 antibody is for IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human LDLRAD3 at AA rangle: 10-90 |
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 LDLRAD3 Conjugated Antibody |
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| C34765 | SAB | 100ul | EUR 397 |
 LDLRAD3 siRNA |
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| 20-abx922395 | Abbexa |
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LDLRAD3 siRNA |
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| 20-abx922396 | Abbexa |
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 LDLRAD3 cloning plasmid |
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| CSB-CL803154HU-10ug | Cusabio | 10ug | EUR 401 |
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Description: A cloning plasmid for the LDLRAD3 gene. |
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 LDLRAD3 Blocking Peptide |
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| 20-abx162318 | Abbexa |
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LDLRAD3 Blocking Peptide |
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| 33R-1897 | Fitzgerald | 100 ug | EUR 180 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LDLRAD3 antibody, catalog no. 70R-9224 |
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 Polyclonal LDLRAD3 antibody - middle region |
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| APR01194G | Leading Biology | 0.05mg | EUR 528 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LDLRAD3 - middle region. This antibody is tested and proven to work in the following applications: |
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 Polyclonal Goat anti-GST α-form |
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| GST-ANTI-1 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
 Human LDLRAD3 shRNA Plasmid |
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| 20-abx965371 | Abbexa |
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 Mouse LDLRAD3 shRNA Plasmid |
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| 20-abx982528 | Abbexa |
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 Mouse Ldlrad3 ELISA KIT |
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| ELI-27814m | Lifescience Market | 96 Tests | EUR 865 |
 Human LDLRAD3 ELISA KIT |
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| ELI-39778h | Lifescience Market | 96 Tests | EUR 824 |
) LDLRAD3 Recombinant Protein (Human) |
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| RP040687 | ABM | 100 ug | Ask for price |
) LDLRAD3 Recombinant Protein (Mouse) |
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| RP147182 | ABM | 100 ug | Ask for price |
 anti- BLOC1S1-Specific antibody |
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| FNab00909 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against BLOC1S1-Specific |
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 anti- BRN2-Specific antibody |
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| FNab00963 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against BRN2-Specific |
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 anti- CAPG-Specific antibody |
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| FNab01249 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CAPG-Specific |
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 anti- Catalase-Specific antibody |
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| FNab01302 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against Catalase-Specific |
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 anti- CCKAR-specific antibody |
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| FNab01377 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CCKAR-specific |
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 anti- CCKBR-specific antibody |
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| FNab01378 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CCKBR-specific |
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 anti- CCR2-specific antibody |
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| FNab01390 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CCR2-specific |
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 anti- CCT6A-Specific antibody |
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| FNab01401 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CCT6A-Specific |
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 anti- CDH10-specific antibody |
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| FNab01546 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CDH10-specific |
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 anti- CDK1-Specific antibody |
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| FNab01552 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CDK1-Specific |
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 anti- CEACAM3-Specific antibody |
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| FNab01578 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CEACAM3-Specific |
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 anti- CEP350-Specific antibody |
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| FNab01603 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CEP350-Specific |
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 anti- CES7-Specific antibody |
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| FNab01618 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CES7-Specific |
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 anti- CHST13-Specific antibody |
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| FNab01693 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against CHST13-Specific |
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 anti- CISD2-Specific antibody |
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| FNab01719 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CISD2-Specific |
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 anti- CPNE9-Specific antibody |
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| FNab01932 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CPNE9-Specific |
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 anti- CPT1B-specific antibody |
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| FNab01944 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against CPT1B-specific |
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 anti- CPT1C-specific antibody |
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| FNab01946 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CPT1C-specific |
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 anti- CRLS1-Specific antibody |
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| FNab01983 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against CRLS1-Specific |
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 anti- CST2-Specific antibody |
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| FNab02033 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CST2-Specific |
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 anti- CSTL1-Specific antibody |
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| FNab02041 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CSTL1-Specific |
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 anti- CUL4A-Specific antibody |
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| FNab02078 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CUL4A-Specific |
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 anti- CXCR3B-specific antibody |
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| FNab02101 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CXCR3B-specific |
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 anti- CXCR7-Specific antibody |
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| FNab02107 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against CXCR7-Specific |
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 anti- CYP1A2-Specific antibody |
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| FNab02148 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CYP1A2-Specific |
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 anti- CYP2E1-Specific antibody |
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| FNab02159 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CYP2E1-Specific |
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 anti- CYP4F11-Specific antibody |
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| FNab02171 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CYP4F11-Specific |
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 anti- CYP4Z1-Specific antibody |
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| FNab02175 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against CYP4Z1-Specific |
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 anti- DAPK2-Specific antibody |
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| FNab02241 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against DAPK2-Specific |
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 anti- DCC-Specific antibody |
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| FNab02262 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against DCC-Specific |
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 anti- DGKK-Specific antibody |
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| FNab02360 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against DGKK-Specific |
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 anti- DLL1-Specific antibody |
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| FNab02415 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against DLL1-Specific |
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 anti- DOCK180-Specific antibody |
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| FNab02493 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against DOCK180-Specific |
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 anti- DR5-Specific antibody |
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| FNab02530 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against DR5-Specific |
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 anti- EDG7-Specific antibody |
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| FNab02635 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against EDG7-Specific |
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 anti- EGFR-Specific antibody |
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| FNab02669 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against EGFR-Specific |
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 anti- EIF2C1-Specific antibody |
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| FNab02697 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against EIF2C1-Specific |
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 anti- EIF2C3-Specific antibody |
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| FNab02698 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against EIF2C3-Specific |
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 anti- EPHA1-specific antibody |
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| FNab02801 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against EPHA1-specific |
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 anti- EPHA6-Specific antibody |
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| FNab02804 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against EPHA6-Specific |
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 anti- FABP7-Specific antibody |
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| FNab02937 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against FABP7-Specific |
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 anti- FANCA-Specific antibody |
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| FNab03004 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against FANCA-Specific |
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 anti- FcRn-Specific antibody |
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| FNab03063 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against FcRn-Specific |
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 anti- FGF16-Specific antibody |
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| FNab03091 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against FGF16-Specific |
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 anti- FMO2-specific antibody |
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| FNab03169 | FN Test | 100µg | EUR 548.75 |
|
Description: Antibody raised against FMO2-specific |
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 anti- FMO5-specific antibody |
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| FNab03171 | FN Test | 100µg | EUR 548.75 |
|
Description: Antibody raised against FMO5-specific |
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 anti- FOXH1-Specific antibody |
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| FNab03196 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against FOXH1-Specific |
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 anti- FOXL2-Specific antibody |
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| FNab03199 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against FOXL2-Specific |
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 anti- GAB3-Specific antibody |
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| FNab03273 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GAB3-Specific |
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 anti- GABARAPL1-Specific antibody |
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| FNab03276 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GABARAPL1-Specific |
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 anti- GABARAPL2-Specific antibody |
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| FNab03278 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GABARAPL2-Specific |
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 anti- GAC-specific antibody |
|||
| FNab03290 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GAC-specific |
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 anti- GATA4-Specific antibody |
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| FNab03363 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GATA4-Specific |
|||
 anti- GEFT-Specific antibody |
|||
| FNab03416 | FN Test | 100µg | EUR 548.75 |
|
Description: Antibody raised against GEFT-Specific |
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 anti- GLI2-Specific antibody |
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| FNab03477 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GLI2-Specific |
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 anti- GLI3-Specific antibody |
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| FNab03478 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GLI3-Specific |
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 anti- GPR101-Specific antibody |
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| FNab03587 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against GPR101-Specific |
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 anti- GPR123-Specific antibody |
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| FNab03592 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against GPR123-Specific |
|||
 anti- GPR139-Specific antibody |
|||
| FNab03596 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against GPR139-Specific |
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 anti- GPRASP1-Specific antibody |
|||
| FNab03612 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against GPRASP1-Specific |
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 anti- GPRIN3-Specific antibody |
|||
| FNab03616 | FN Test | 100µg | EUR 548.75 |
|
Description: Antibody raised against GPRIN3-Specific |
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 anti- HBA1-Specific antibody |
|||
| FNab03767 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against HBA1-Specific |
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 anti- HBG1-Specific antibody |
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| FNab03772 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against HBG1-Specific |
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 anti- HBM-Specific antibody |
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| FNab03773 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against HBM-Specific |
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 anti- HBQ1-Specific antibody |
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| FNab03776 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against HBQ1-Specific |
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 anti- HBZ-Specific antibody |
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| FNab03780 | FN Test | 100µg | EUR 585 |
|
Description: Antibody raised against HBZ-Specific |
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 anti- HDAC1-specific antibody |
|||
| FNab03795 | FN Test | 100µg | EUR 505.25 |
|
Description: Antibody raised against HDAC1-specific |
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T-cell blasts and at a considerably decrease density on lipopolysaccharide-induced B-cell blasts; 7D4 binding was not detected on better than 95% of nonactivated thymocytes, T cells, or B cells. Competitors binding research indicated that 7D4 fails to inhibit the binding of 3H-labeled human IL-2 to CTLL cells. Nevertheless, 7D4 particularly immunoprecipitated 3H-labeled human IL-2 from detergent extracts of HT2 cells or Con A-induced T-cell blasts that had been pulsed with [3H]IL-2; in distinction, 7D4 didn’t react with free [3H]IL-2. Preliminary biochemical evaluation of immunoprecipitates with 7D4 of detergent extracts from surface-iodinated Con A-activated spleen cells confirmed a serious band having obvious molecular weight of 48,000-62,000.
