FLRT3 Rabbit Polyclonal Antibody

Description: A polyclonal antibody for detection of FLRT3 from Human, Rat. This FLRT3 antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human FLRT3 protein

Description: A polyclonal antibody against FLRT3. Recognizes FLRT3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:1000-1:5000, IF:1:50-1:200

Description: Unconjugated Rabbit polyclonal to FLRT3

Description: Purified Recombinant FLRT3 protein (His tagged)

Description: A polyclonal antibody against FLRT3. Recognizes FLRT3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against FLRT3. Recognizes FLRT3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

Description: A polyclonal antibody against FLRT3. Recognizes FLRT3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Description: A cloning plasmid for the FLRT3 gene.

Description: Leucine-Rich Repeat Transmembrane Protein FLRT3 (FLRT3) is a member of the fibronectin leucine rich transmembrane protein (FLRT) family. Proteins in this family play an role in cell adhesion and/or receptor signalling. FLRT3 is a single-pass type I membrane protein and contains one fibronectin type-III domain, ten LRR (leucine-rich) repeats, one LRRCT domain, and one LRRNT domain. FLRT3 may have a function in cell adhesion and/or receptor signaling. FLRT3 may regulate cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge.

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3)

Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3). This antibody is labeled with PE.

Description: Description of target: Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:B1H234 (FLRT3_RAT)UniProtKB:Q8BGT1 (FLRT3_MOUSE)2 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.9"FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth."_x005F_x005F_x000D_Tsuji L., Yamashita T., Kubo T., Madura T., Tanaka H., Hosokawa K., Tohyama M._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 313:1086-1091(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY.Ref.11"Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion."_x005F_x005F_x000D_Lu Y.C., Nazarko O.V., Sando R. III, Salzman G.S., Suedhof T.C., Arac D._x005F_x005F_x000D_Structure 23:1678-1691(2015) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 29-357 IN COMPLEX WITH ADGRL3, SUBUNIT, INTERACTION WITH ADGRL3; UNC5B AND UNC5D, SUBCELLULAR LOCATION, DISULFIDE BOND, GLYCOSYLATION AT ASN-226, MUTAGENESIS OF ASP-38; TYR-43; ASN-45; ARG-47; TYR-64; TYR-89; TYR-91; ARG-181 AND ASP-183. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.57 ng/mL

Description: Description of target: Leucine-rich repeat transmembrane protein FLRT3 is a protein that in humans is encoded by the FLRT3 gene. It is mapped to 20p12.1. This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. ;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <50pg/ml

Description: A Rabbit polyclonal antibody against Human Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3). This antibody is labeled with APC-Cy7.