Abstract
Hantavirus cardiopulmonary syndrome (HCPS) is a rare but frequently fatal acute zoonotic viral infection in rural North America. The rapidity of progression from a febrile prodrome to cardiogenic shock and non-cardiogenic pulmonary oedema requiring intensive care creates great diagnostic urgency and the need for a rapid screening tool. In this retrospective cohort study, 2 pathologists graded blinded peripheral blood smears from 52 patients with HCPS and 128 seronegative patients referred for diagnosis of suspected hantavirus infection. During the prodromal phase, thrombocytopenia was the only consistent abnormality and could be used to indicate hantavirus serologic testing.
After the onset of radiographically detected pulmonary oedema, the presence of 4 of 5 findings (thrombocytopenia, myelocytosis, hemoconcentration, lack of significant toxic granulation in neutrophils, and greater than 10% lymphocytes with immunoblastic morphology) has a sensitivity for HCPS of 96 % and a specificity of 99% and no HCPS patients requiring intensive care were missed. While each abnormality is commonly seen, the combination of at least 4 of these CBC count data and peripheral blood smear findings can guide early treatment and patient transport decisions until rapid and specific serologic testing is widely available.
Product details
- Product Type: Qualitative Rapid Diagnostic Kit (Immunochromatography)
- Sample and test volume: Nasopharyngeal swab 4 drops (190㎕)
- Reading time: 15 minutes
- Shelf life: 24 months
- Storage temperature: Ambient temperature (1~30℃)
- Package: 30T/Box
Coronavirus disease-2019 (COVID-19)
COVID-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Common symptoms include fever, cough, fatigue, shortness of breath (dyspnea), sore throat, nausea, diarrhoea, and loss of taste and smell. While most cases result in mild symptoms, some progress to acute respiratory distress syndrome (ARDS) likely precipitated by a cytokine storm, multi-organ failure, septic shock, and blood clots. The time from exposure to onset of symptoms is usually about five days but can range from two to fourteen days.
The virus is spread primarily between people during close contact, most often through droplets produced by coughing, sneezing, and talking. Less commonly, people can become infected by touching a contaminated surface and then touching their face. It is most contagious during the first three days after symptoms start, although spread before symptoms appear and from people who do not show symptoms is possible.
Characteristics
- Very easy to diagnose COVID-19 from the acute stage of initial infection to the convalescent stage.
- As a point-of-care test (POCT), it is optimized for on-site diagnosis.
- Store at room temperature (1~30°C).
- Interpret test results very quickly.
