The distribution of tau in the mammalian central nervous system.

The distribution of tau in the mammalian central nervous system.

We now have decided the biochemical and immunocytochemical localization of the heterogeneous microtubule-associated protein tau utilizing a monoclonal antibody that binds to the entire tau polypeptides in each bovine and rat mind. Utilizing immunoblot assays and aggressive enzyme-linked immunosorbent assays, now we have proven tau to be extra considerable in bovine white matter extracts and microtubules than in extracts