Heat-labile UDG
Description Uracil-DNA Glycosylase cleaves uracil from dU-containing DNA by breaking the N-glycosidic bond between the uracil base and the sugar backbone. This cleavage generates alkali-sensitive apyrimidinic sites that DNA polymerase blocks from replication or prevents from becoming a hybridization site. Single-stranded and double-stranded dU-containing DNA are substrates for uracil-DNA glycosylase, whereas normal dT-containing RNA and…
