Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1.

The monoclonal antibody (mAb) ED1 is getting used extensively as a marker for rat macrophages. The distribution of the acknowledged antigen in tissues and remoted cells strongly helps this use as a macrophage marker, because the majority of macrophages are acknowledged and solely seldomly are different cell sorts stained by mAb ED1. Within the current research we additional characterised the acknowledged antigen by an in depth description of the localization of the antigen and by figuring out biochemical and purposeful properties. We present that the antigen is expressed on the membranes of cytoplasmic granules, like phagolysosomes, in addition to on the cell floor.

The quantity of ED1 expression in a single cell could be correlated to phagocytic exercise of the respective cell sort, however the mAb ED1 shouldn’t be in a position to block latex phagocytosis or bacterial killing. Spinal wire trauma results in lack of motor, sensory and autonomic features under the lesion. Restoration may be very restricted, due partly to neurite development inhibitory myelin proteins, particularly Nogo-A. Two neutralizing antibodies in opposition to Nogo-A have been used to check restoration and axonal regeneration after spinal wire lesions. Comparability with earlier research of localization of different glutamate receptor sorts revealed that NMDAR1 might colocalize with these different sorts in lots of neurons all through the nervous system.

Three months previous Lewis rats have been examined in sensory-motor duties (open discipline locomotion, crossing of ladder rungs and slender beams, the CatWalk(R) runway, reactions to warmth and von Frey hairs). A T-shaped lesion was made at T8, and an intrathecal catheter delivered extremely purified anti-Nogo-A monoclonal IgGs or unspecific IgGs for two weeks. A greater final result in motor habits was obtained as early as two weeks after lesion within the animals receiving the Nogo-A antibodies. Collectively, these outcomes counsel that 7D4 detects an epitope on the IL-2 receptor distal to the ligand binding website or one other molecule that bodily associates with the receptor.

Gentle and electron microscope distribution of the NMDA receptor subunit NMDAR1 within the rat nervous system utilizing a selective anti-peptide antibody.

NMDA receptors play key roles in synaptic plasticity and neuronal growth, and could also be concerned in studying, reminiscence, and compensation following harm. A polyclonal antibody that acknowledges 4 of seven splice variants of NMDAR1 was made utilizing a C-terminus peptide (30 amino acid residues). NMDAR1 is the main NMDA receptor subunit, present in most or all NMDA receptor complexes. On immunoblots, this antibody labeled a single main band migrating at M(r) = 120,000. The antibody didn’t cross-react with extracts from transfected cells expressing different glutamate receptor subunits, nor did it label non-neuronal tissues.

Immunostained vibratome sections of rat tissue confirmed labeling in lots of neurons in most constructions within the mind, in addition to within the cervical spinal wire, dorsal root and vestibular ganglia, and in pineal and pituitary glands. Staining was average to dense within the olfactory bulb, neocortex, striatum, some thalamic and hypothalamic nuclei, the colliculi, and lots of reticular, sensory, and motor neurons of the brainstem and spinal wire. The densest stained cells included the pyramidal and hilar neurons of the CA3 area of the hippocampus

Purkinje cells of the cerebellum, supraoptic and magnocellular paraventricular neurons of the hypothalamus, inferior olive, purple nucleus, lateral reticular nucleus, peripheral dorsal cochlear nucleus, and motor nuclei of the decrease brainstem and spinal wire. Ultrastructural localization of immunostaining was examined within the hippocampus, cerebral cortex, and cerebellar cortex. The most important staining was in postsynaptic densities apposed by unstained presynaptic terminals with spherical or primarily spherical vesicles, and in related dendrites. The sample of staining matched that of earlier in situ hybridization however differed considerably from that of binding research, implying that a number of sorts of NMDA receptors exist.

Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1.

Antibodies to tumor necrosis issue alfa attenuate hepatic necrosis and irritation brought on by power publicity to ethanol within the rat.

Tumor necrosis issue (TNF)alpha, a pivotal cytokine concerned in irritation, is produced primarily by Kupffer cells within the liver. It has been proven that inactivation of Kupffer cells prevents alcohol-induced liver harm; due to this fact, the aim of this research was to find out if neutralizing anti-TNF-alpha antibody can be efficient. Male Wistar rats have been uncovered to ethanol constantly for as much as four weeks by way of intragastric feeding utilizing an enteral feeding mannequin. Earlier than ethanol publicity, polyclonal anti-mouse TNF-alpha rabbit serum was injected (2.zero mg/kg intravenously).

There have been no important variations in physique weight, imply ethanol focus, or cyclic patterns of ethanol in urine when ethanol- and ethanol plus antibody-treated teams have been in contrast. Expression of TNF-alpha and macrophage inflammatory protein 2 (MIP-2) messenger RNA (mRNA), decided utilizing reverse transcription-polymerase chain response, was three- to four-fold increased in livers of ethanol-treated rats than in these of rats fed an ethanol-free, high-fat management food regimen. As well as, MIP-2 ranges have been additionally elevated when detected by Northern blot evaluation. Anti-TNF-alpha antibody didn’t have an effect on expression of mRNA for interleukin (IL) 1alpha, IL-6, reworking development issue beta1, or TNF-alpha.

Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx213141
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx213249
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Microtubule Associated Protein Tau/Tau Protein (MAPT) Antibody
abx038349-100ug 100 ug
EUR 391
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx012886
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx012887
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx012906
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx012907
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
abx031498-400ul 400 ul
EUR 523
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
abx031498-80l 80 µl
EUR 286
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
abx238505-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.
Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx241245
  • EUR 411.00
  • EUR 300.00
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Microtubule Associated Protein Tau/Tau Protein (MAPT) Antibody
abx411491-01ml 0.1 ml
EUR 453
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx329863
  • EUR 314.00
  • EUR 244.00
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
abx332120-100ul 100 ul
EUR 425
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx327131
  • EUR 314.00
  • EUR 244.00
  • 100 ug
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx327132
  • EUR 314.00
  • EUR 244.00
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx327424
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx327960
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx328321
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx328322
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx323528
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx317889
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  • EUR 1845.00
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  • EUR 300.00
  • 100 ug
  • 1 mg
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody
20-abx001022
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  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
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TAU protein
E62B006 20ug
EUR 382
Tau antibody
20R-1636 100 ug
EUR 673
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1958 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1959 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1963 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1964 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1965 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1966 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1967 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1968 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-1969 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2092 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2102 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2182 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2272 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2273 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2275 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2276 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2277 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2278 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2279 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2280 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2281 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2407 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2420 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-2692 50 ug
EUR 281
Description: Rabbit polyclonal Tau antibody
Tau antibody
20R-TG001 250 ul
EUR 349
Description: Goat polyclonal Tau antibody
Tau Antibody
21570-100ul 100ul
EUR 252
Tau Antibody
21570-50ul 50ul
EUR 187
TAU antibody
70R-18412 50 ul
EUR 435
Description: Rabbit polyclonal TAU antibody
Tau antibody
70R-10637 1 ml
EUR 693
Description: Affinity purified Chicken polyclonal Tau antibody
Tau antibody
70R-11904 100 ug
EUR 403
Description: Rabbit polyclonal Tau antibody
Tau antibody
70R-13655 100 ul
EUR 430
Description: Affinity purified Rabbit polyclonal Tau antibody
Tau Antibody
48195-100ul 100ul
EUR 333
Tau Antibody
48195-50ul 50ul
EUR 239
Tau Antibody
3549R-100
EUR 316
Tau Antibody
3549R-30T
EUR 146
Tau antibody
10R-T101a 100 ug
EUR 553
Description: Mouse monoclonal Tau antibody
Tau antibody
10R-T102a 100 ug
EUR 673
Description: Mouse monoclonal Tau antibody
Tau antibody
10-B9091MD01-MD 1 mg
EUR 192
Description: Monoclonal Tau antibody
Tau antibody
10R-7903 100 ug
EUR 305
Description: Mouse monoclonal Tau antibody
Tau Antibody
48681-100ul 100ul
EUR 333
Tau Antibody
48681-50ul 50ul
EUR 239
Tau Antibody
49155-100ul 100ul
EUR 333
Tau Antibody
49155-50ul 50ul
EUR 239
Tau antibody
70R-TG010 100 ug
EUR 300
Description: Affinity purified Goat polyclonal Tau antibody
Tau antibody
70R-37532 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37533 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37535 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37536 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37537 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37538 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37539 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37540 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
Tau antibody
70R-37541 100 ug
EUR 273
Description: Rabbit Polyclonal Tau antibody
TAU antibody
70R-50036 100 ul
EUR 287
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-50037 100 ul
EUR 287
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-50038 100 ul
EUR 287
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-50039 100 ul
EUR 287
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-50040 100 ul
EUR 244
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-50041 100 ul
EUR 244
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-50042 100 ul
EUR 244
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-51580 100 ul
EUR 287
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-51581 100 ul
EUR 287
Description: Purified Polyclonal TAU antibody
TAU antibody
70R-51582 100 ul
EUR 287
Description: Purified Polyclonal TAU antibody
Tau antibody
70R-32541 100 ug
EUR 327
Description: Rabbit polyclonal Tau antibody
Tau antibody
70R-32543 100 ug
EUR 327
Description: Rabbit polyclonal Tau antibody
Tau antibody
70R-32545 100 ug
EUR 327
Description: Rabbit polyclonal Tau antibody
Tau antibody
70R-32548 100 ug
EUR 327
Description: Rabbit polyclonal Tau antibody
Tau antibody
70R-32552 100 ug
EUR 327
Description: Rabbit polyclonal Tau antibody
Tau antibody
70R-32554 100 ug
EUR 327
Description: Rabbit polyclonal Tau antibody
Tau Antibody
AF6141 200ul
EUR 304
Description: Tau Antibody detects endogenous levels of total Tau.
Tau Antibody
ABF6141 100 ug
EUR 438
TAU antibody
PAab10118 100 ug
EUR 412
Tau Antibody
P1026-01m 0.1m
EUR 191
Tau Antibody
P1026-1ml 1ml
EUR 572
Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody (HRP)
20-abx314428
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody (FITC)
20-abx314429
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Antibody (Biotin)
20-abx314430
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Tau (Tau 46)
MO18002 100 ul
EUR 483
tau-F protein/Microtubule-associated protein tau
E21-H19 10ug
EUR 343
Anti-Tau Antibody (monoclonal, TAU-2)
MA1093 100ug/vial
EUR 334
Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx263440
  • EUR 230.00
  • EUR 1609.00
  • EUR 328.00
  • 1 µg
  • 50 ug
  • 5 ug
  • Shipped within 5-10 working days.
Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx262449
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.
Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx262455
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
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Microtubule Associated Protein Tau / Tau Protein (MAPT) Protein
20-abx262840
  • EUR 328.00
  • EUR 6397.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.
Microtubule Associated Protein Tau / Tau Protein Phospho-Ser235 (MAPT pS235) Antibody
20-abx012569
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
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  • 300 µg
  • Shipped within 5-10 working days.
Microtubule Associated Protein Tau / Tau Protein Phospho-Ser396 (MAPT pS396) Antibody
20-abx012570
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
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  • 300 µg
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14.3.3 tau protein
30R-1109 100 ug
EUR 457
Description: Purified recombinant Human 14.3.3 tau protein
p-Tau antibody
23041-100ul 100ul
EUR 390
Tau (396) antibody
20R-2956 100 ul
EUR 393
Description: Rabbit polyclonal Tau(396) antibody
Phospho-Tau antibody
70R-12468 100 ul
EUR 503
Description: Rabbit polyclonal Phospho Tau antibody
Phospho-Tau Antibody
3550R-100
EUR 403
14.3.3 tau antibody
10R-1129 100 ul
EUR 316
Description: Mouse monoclonal 14-3-3 tau antibody
Tau 13 antibody
10R-6745 100 ul
EUR 705
Description: Mouse monoclonal Tau 13 antibody
Tau 13 antibody
10R-8037 100 ul
EUR 548
Description: Mouse monoclonal Tau 13 antibody
Tau Polyclonal Antibody
41479-100ul 100ul
EUR 252
Tau Polyclonal Antibody
41479-50ul 50ul
EUR 187
Tau Polyclonal Antibody
41480-100ul 100ul
EUR 252

Nonetheless, MIP-2 mRNA expression, which is regulated by TNF-alpha, was decreased considerably by anti-TNF-alpha antibody therapy. Serum aspartate transaminase ranges have been elevated in ethanol-treated rats to 136 +/- 12 IU/L after four weeks however solely reached 90 +/- 5 IU/L (P < .05) in rats handled with anti-TNF-alpha antibody. The hepatic irritation and necrosis noticed in ethanol-fed rats have been attenuated considerably by antibody therapy, and steatosis was not. These outcomes help the speculation that TNF-alpha performs an vital position in irritation and necrosis in alcohol-induced liver harm and that therapy with anti-TNF-alpha antibody could also be therapeutically helpful on this illness.