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Affiliation evaluation of the surfactant protein-C gene

Posted on October 1, 2020 By Valerie Holmes

The genetic foundation of pure antibody titers of younger wholesome pigs and relationships with illness resilience

Background: Sickness resilience is the flexibleness to maintain up effectivity beneath pathogen publicity nevertheless is troublesome to choose for because of breeding populations are raised beneath extreme properly being. Alternative for resilience requires a trait that is heritable, easy to measure on healthful animals, and genetically correlated with resilience. Pure antibodies (NAb) are important parts of the innate immune system and are found to be heritable and associated to sickness susceptibility in dairy cattle and poultry. Our objective was to investigate NAb and entire IgG in blood of healthful, youthful pigs as potential indicator traits for sickness resilience.

 

Outcomes: Info have been from Yorkshire x Landrace pigs, with IgG and IgM NAb (Four antigens) and entire IgG measured by ELISA in blood plasma collected ~ 1 week after weaning, earlier to their publicity to a pure polymicrobial downside. Heritability estimates have been lower for IgG NAb (0.12 to 0.24, + 0.05) and for entire IgG (0.19 + 0.05) than for IgM NAb (0.33 to 0.53, + 0.07) nevertheless maternal outcomes have been larger for IgG NAb (0.41 to 0.52, + 0.03) and for entire IgG (0.19 + 0.05) than for IgM NAb (0.00 to 0.10, + 0.04).

 

Phenotypically, IgM NAb titers have been moderately correlated with each other (frequent 0.60), as have been IgG NAb titers (frequent 0.42), nevertheless correlations between IgM and IgG NAb titers have been weak (frequent 0.09). Phenotypic correlations of entire IgG have been cheap with NAb IgG (frequent 0.46) nevertheless weak with NAb IgM (frequent 0.01).

 

Estimates of genetic correlations amongst NAb confirmed associated patterns nevertheless with small SE, with estimates averaging 0.76 amongst IgG NAb, 0.63 amongst IgM NAb, 0.17 between IgG and IgM NAb, 0.64 between entire IgG and IgG NAb, and 0.13 between entire IgG and IgM NAb. Phenotypically, pigs that survived had barely elevated ranges of NAb and entire IgG than pigs that died. Genetically, elevated ranges of NAb tended to be associated to higher sickness resilience based on lower mortality and fewer parenteral antibiotic therapies. Genome-wide affiliation analyses for NAb titers acknowledged a lot of genomic areas, with a lot of candidate genes for immune response.

 

Conclusions: Ranges of NAb in blood of healthful youthful piglets are heritable and potential genetic indicators of resilience to polymicrobial sickness.

 

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Cixiophiopogon A

HY-N2175 MedChemExpress 5mg
EUR 705

Saikosaponin F

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EUR 243

Hypaphorine

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EUR 705

Pinoresinol dimethyl ether

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EUR 108

Acetylshikonin

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EUR 243

Episyringaresinol 4'-O-β-D-glncopyranoside

HY-N2182 MedChemExpress 10mg
EUR 838

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EUR 320

(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one

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Deoxyshikonin

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×

 

Affiliation analysis of the surfactant protein-C gene to childhood bronchial bronchial asthma

 

Targets: This analysis targets to elucidate the molecular variability throughout the SFTPC gene in a childhood persistent respiratory sickness, bronchial bronchial asthma, throughout the Tunisian inhabitants and to ascertain the implications based on a case-control analysis of p.Thr138Asn (T138N) and p.Ser186Asn (S186N) variants.

 

Methods: We used direct sequencing for the genotyping of the SFTPC gene inside 101 asthmatic kids. The analysis of T138N and S186N variants in 110 controls is carried out by the PCR-RFLP technique. Outcomes: The molecular analysis revealed 26 variants along with 24 intronic variations and a pair of exonic variations (T138N and S186N) with respective frequencies of 16.8% and 18.3%. We carried out a case-control analysis of the two acknowledged exonic

variations. A particular genotypic and allelic distribution between the two groups was well-known. Solely the T138N polymorphism confirmed a significant affiliation with bronchial bronchial asthma sickness (p < 10-3).

 

Statistical analysis elaborated Four haplotypes with the subsequent frequencies in victims vs controls: 138Thr-186Ser (79.5% vs 57.6%), 138Thr-186Asn (3.7% vs 7.8%), 138Asn-186Thr (2.2% vs 20.2%) and 138Asn-186Asn (14.6% vs 14.4%). A serious distinction (p < 10-3) was highlighted in haplotype distribution. The 138Asn-186Ser (OR [95%CI] = 0.14[0.04-0.54], p = 0.004, R2=0.93) and 138Thr-186Asn (OR [95%CI] = 0.35[0.12-0.54], p = 0.047, R2=0.88) haplotypes confirmed a dangerous affiliation with bronchial bronchial asthma which may symbolize a defending problem in opposition to the sickness.

 

Conclusion: In Tunisia, this work constitutes the first report throughout the SFTPC gene and highlights the genetic variability of the SFTPC gene in bronchial bronchial asthma. On account of this reality, the case-controls analysis is also useful throughout the analysis of surfactant proteins dysfunction in persistent respiratory sickness at an early age.

 

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HNRNPC Antibody

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Phospho-SYT1 (Ser309) Antibody

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NRSN1 Antibody

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NRSN1 Antibody

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RABL2A Antibody

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RABL2A Antibody

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HDAC3 Antibody

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HDAC3 Antibody

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AKR1A1 Antibody

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AKR1A1 Antibody

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CLCN4 Antibody

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CLCN4 Antibody

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ATF1 Antibody

CSB-PA968509- Cusabio
EUR 335
Description: A polyclonal antibody against ATF1. Recognizes ATF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

ATF1 Antibody

CSB-PA968509-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against ATF1. Recognizes ATF1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

Phospho-MEF2A (Ser408) Antibody

CSB-PA968646- Cusabio
EUR 335
Description: A polyclonal antibody against Phospho-MEF2A (Ser408). Recognizes Phospho-MEF2A (Ser408) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-MEF2A (Ser408) Antibody

CSB-PA968646-100ul Cusabio 100ul
EUR 362
Description: A polyclonal antibody against Phospho-MEF2A (Ser408). Recognizes Phospho-MEF2A (Ser408) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

WISP2 Antibody

CSB-PA968927- Cusabio
EUR 335
Description: A polyclonal antibody against WISP2. Recognizes WISP2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

WISP2 Antibody

CSB-PA968927-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against WISP2. Recognizes WISP2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-GRIN2B (Tyr1474) Antibody

CSB-PA969425- Cusabio
EUR 335
Description: A polyclonal antibody against Phospho-GRIN2B (Tyr1474). Recognizes Phospho-GRIN2B (Tyr1474) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200

Phospho-GRIN2B (Tyr1474) Antibody

CSB-PA969425-100ul Cusabio 100ul
EUR 362
Description: A polyclonal antibody against Phospho-GRIN2B (Tyr1474). Recognizes Phospho-GRIN2B (Tyr1474) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200

PMAIP1 Antibody

CSB-PA969433- Cusabio
EUR 335
Description: A polyclonal antibody against PMAIP1. Recognizes PMAIP1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

PMAIP1 Antibody

CSB-PA969433-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against PMAIP1. Recognizes PMAIP1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-ZAP70 (Tyr319) Antibody

CSB-PA969675- Cusabio
EUR 335
Description: A polyclonal antibody against Phospho-ZAP70 (Tyr319). Recognizes Phospho-ZAP70 (Tyr319) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

Phospho-ZAP70 (Tyr319) Antibody

CSB-PA969675-100ul Cusabio 100ul
EUR 362
Description: A polyclonal antibody against Phospho-ZAP70 (Tyr319). Recognizes Phospho-ZAP70 (Tyr319) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

RPS4X Antibody

CSB-PA969688- Cusabio
EUR 335
Description: A polyclonal antibody against RPS4X. Recognizes RPS4X from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

RPS4X Antibody

CSB-PA969688-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against RPS4X. Recognizes RPS4X from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:3000, IF:1:100-1:500

TUBB3 Antibody

CSB-PA969690- Cusabio
EUR 335
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

TUBB3 Antibody

CSB-PA969690-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

NT5C1B Antibody

CSB-PA969848- Cusabio
EUR 335
Description: A polyclonal antibody against NT5C1B. Recognizes NT5C1B from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

NT5C1B Antibody

CSB-PA969848-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against NT5C1B. Recognizes NT5C1B from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

AKT1 (Ab-450) Antibody

CSB-PA969941- Cusabio
EUR 335
Description: A polyclonal antibody against AKT1 (Ab-450). Recognizes AKT1 (Ab-450) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

AKT1 (Ab-450) Antibody

CSB-PA969941-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against AKT1 (Ab-450). Recognizes AKT1 (Ab-450) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

Phospho-MAP2K4 (Ser80) Antibody

CSB-PA970074- Cusabio
EUR 335
Description: A polyclonal antibody against Phospho-MAP2K4 (Ser80). Recognizes Phospho-MAP2K4 (Ser80) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

Phospho-MAP2K4 (Ser80) Antibody

CSB-PA970074-100ul Cusabio 100ul
EUR 362
Description: A polyclonal antibody against Phospho-MAP2K4 (Ser80). Recognizes Phospho-MAP2K4 (Ser80) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

RAB29 Antibody

CSB-PA970360- Cusabio
EUR 335
Description: A polyclonal antibody against RAB29. Recognizes RAB29 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

RAB29 Antibody

CSB-PA970360-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against RAB29. Recognizes RAB29 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

KIR2DL5B Antibody

CSB-PA970470- Cusabio
EUR 335
Description: A polyclonal antibody against KIR2DL5B. Recognizes KIR2DL5B from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

KIR2DL5B Antibody

CSB-PA970470-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against KIR2DL5B. Recognizes KIR2DL5B from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF;IF:1:100-1:500

IKZF3 Antibody

CSB-PA970658- Cusabio
EUR 335
Description: A polyclonal antibody against IKZF3. Recognizes IKZF3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

IKZF3 Antibody

CSB-PA970658-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against IKZF3. Recognizes IKZF3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

USP13 Antibody

CSB-PA970742- Cusabio
EUR 335
Description: A polyclonal antibody against USP13. Recognizes USP13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

USP13 Antibody

CSB-PA970742-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against USP13. Recognizes USP13 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

ABCD4 Antibody

CSB-PA970746- Cusabio
EUR 335
Description: A polyclonal antibody against ABCD4. Recognizes ABCD4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

ABCD4 Antibody

CSB-PA970746-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against ABCD4. Recognizes ABCD4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

AATF Antibody

CSB-PA970851- Cusabio
EUR 335
Description: A polyclonal antibody against AATF. Recognizes AATF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

AATF Antibody

CSB-PA970851-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against AATF. Recognizes AATF from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

MOB1B Antibody

CSB-PA970943- Cusabio
EUR 335
Description: A polyclonal antibody against MOB1B. Recognizes MOB1B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

MOB1B Antibody

CSB-PA970943-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against MOB1B. Recognizes MOB1B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

PLG Antibody

CSB-PA970985- Cusabio
EUR 335
Description: A polyclonal antibody against PLG. Recognizes PLG from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

PLG Antibody

CSB-PA970985-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against PLG. Recognizes PLG from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

OXR1 Antibody

CSB-PA971107- Cusabio
EUR 335
Description: A polyclonal antibody against OXR1. Recognizes OXR1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

OXR1 Antibody

CSB-PA971107-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against OXR1. Recognizes OXR1 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

NBPF5P Antibody

CSB-PA971232- Cusabio
EUR 335
Description: A polyclonal antibody against NBPF5P. Recognizes NBPF5P from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

NBPF5P Antibody

CSB-PA971232-100ul Cusabio 100ul
EUR 316
Description: A polyclonal antibody against NBPF5P. Recognizes NBPF5P from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

KCNJ4 Antibody

CSB-PA971432- Cusabio
EUR 335
Description: A polyclonal antibody against KCNJ4. Recognizes KCNJ4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000
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July 2022
M T W T F S S
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Categories

  • Antibodies
  • Blog
  • Cultrex
  • Default
  • Dot
  • EIA
  • electrophoresis
  • Exosomes
  • Gels
  • Goat
  • HRP
  • Isotypes
  • NATtrol
  • Particles
  • Rabbit
  • Species

Recent Posts

  • Mycoplasma pneumoniae Recombinants
  • Canis lupus familiaris Recombinants
  • Cricetulus griseus Recombinants
  • Heat-labile UDG
  • Immunemed HANTA RAPID
July 2022
M T W T F S S
 123
45678910
11121314151617
18192021222324
25262728293031
« Jan    

Categories

  • Antibodies
  • Blog
  • Cultrex
  • Default
  • Dot
  • EIA
  • electrophoresis
  • Exosomes
  • Gels
  • Goat
  • HRP
  • Isotypes
  • NATtrol
  • Particles
  • Rabbit
  • Species

Recent Posts

  • Mycoplasma pneumoniae Recombinants
  • Canis lupus familiaris Recombinants
  • Cricetulus griseus Recombinants
  • Heat-labile UDG
  • Immunemed HANTA RAPID

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