Subsequent technology sequencing reveals a novel pathogenic variant within the ATMgene
Introduction: Ataxia telangiectasia (A-T) is a unusual autosomal recessive multisystemic sickness. Victims with the A-T syndrome present a broad spectrum of sickness phenotypes. The ATM (ataxia telangiectasia mutated) gene, the one causative gene for A-T.
Methodology: A affected individual of Persian origin presenting with typical A-T was referred to our genetics center for specialised genetic counseling and testing. Centered next-generation sequencing (NGS) was utilized. Sanger sequencing was used to substantiate the candidate variant. Modeling was carried out using the SWISS-MODEL server.Outcomes: A homozygous stop-gain variant c.829G > T (p.E277*) was found throughout the ATM gene. This variant was confirmed by Sanger sequencing and modeling of native building and truncated building was carried out.
Conclusion: Up to now, just a few pathogenic variants of the ATM gene have been reported from the Iranian inhabitants. The discovering has implications in molecular diagnostic for A-T in Iran.

isvee13
Product not found
Familial dilated cardiomyopathy introduced on by a novel variant throughout the Lamin A/C gene: a case report
Background: Familial dilated cardiomyopathy (FDCM) is generally inherited as an autosomal dominant trait. The Lamin A/C (LMNA) gene variants have been acknowledged to be associated to DCM, conductive system issues, form 2 Emery-Dreifuss muscular dystrophy and numerous different completely different issues. Proper right here, we reported a novel variant throughout the LMNA gene that’s prone to be related to FDCM.
Case presentation: A 30-year-old youthful man was hospitalized for chest tightness, extreme fatigue, palpitation and impaired train tolerance. He had scientific traits along with cardiac dilatation, atrial tachyarrhythmia, excessive conductive system issues, and dyskinesia of every increased limbs and the neck. Genetic sequence analysis indicated that the affected individual carried a novel c.1325 T>C heterozygous LMNA gene variant. Catheter ablation and cardiac resynchronization treatment with pacing carry out (CRT-P) have been carried out to take care of the arrhythmia.
Conclusion: The variant c.1325 T>C is a novel variant throughout the LMNA gene that has not been beforehand reported. Youthful victims with DCM, conductive system issues and skeletal myopathy should be alert to the potential for LMNA gene variant. Cardiac resynchronization treatment (CRT) is also an inexpensive choice for affected individual carrying a LMNA gene variant with third-degree atrioventricular block even when the left ventricular ejection fraction is preserved with the intention to cease the deterioration of cardiac carry out introduced on by correct ventricular pacing dependency.
Genetic analysis of children with congenital ocular anomalies in three ecological areas of Nepal: a piece II of Nepal pediatric ocular sicknesses analysis
Background: Genetic eye sicknesses symbolize a giant and heterogeneous group of childhood ocular morbidity. Specific individual sicknesses may set off numerous structural anomalies and developmental choices. Nepal Pediatric Ocular Sickness Analysis (NPODS) was a population-based epidemiological analysis carried out all through three ecological areas of Nepal to search out out the prevalence and etiology of childhood ocular morbidity and blindness. In Half II of this analysis, genetic analysis was carried out for teenagers who’ve been found to have congenital ocular anomalies.
Methodology: It was a cross sectional descriptive analysis. A whole of 10,270 kids all through three completely completely different ecological areas in Nepal (Low lands, hills, and mountains) underwent ocular examinations in NPODS. Out of 374 (3.6%) of children with ocular abnormalities, 30 have been thought-about congenital in nature. Centered genetic analysis, along with genotyping for genes explicit to presenting phenotype, was carried out for 25 kids using serum samples.
Outcomes: Out of 25 kids, 18 had important genetic outcomes. Analysis revealed one missense alteration G12411T of Zinc Finger Homeobox 4 (ZFHX4) gene in a single participant amongst 10 with congenital ptosis and one different missense variation T > C P. Y374 C of Signaling Receptor and Transporter Retinol 6 (STRA6) gene in a single participant amongst Three with microphthalmos.
Conclusion: The analysis is first of its kind from Nepal and mutant genes have been distinctive to Nepalese Inhabitants. Extra analysis of genetic parts is crucial to increased understand genetic affiliation with ocular sicknesses and conditions. This helps extra in genetic counseling and probably gene treatment to forestall blindness from these conditions.
Doxorubicin Hydrochloride |
20-abx076623 |
Abbexa |
|
|
- Shipped within 5-12 working days.
|
Doxorubicin hydrochloride |
TNC00267 |
ChemNorm |
20mg |
Ask for price |
Doxorubicin hydrochloride USP |
D005-10MG |
TOKU-E |
10 mg |
EUR 166 |
Doxorubicin hydrochloride USP |
D005-25MG |
TOKU-E |
25 mg |
EUR 301 |
Doxorubicin Hydrochloride (Autophagy inducer) |
SIH-390-10MG |
Stressmarq |
10 mg |
EUR 193 |
- Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefo
- Show more
|
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
Doxorubicin Hydrochloride (Autophagy inducer) |
SIH-390-50MG |
Stressmarq |
50 mg |
EUR 529 |
- Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefo
- Show more
|
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM).. |
Erlotinib, Hydrochloride Salt |
1588-100 |
Biovision |
|
EUR 169 |
Erlotinib, Hydrochloride Salt |
1588-1000 |
Biovision |
|
EUR 398 |
Doxorubicin |
abx188695-1g |
Abbexa |
1 g |
EUR 467 |
- Shipped within 1-2 weeks.
|
Doxorubicin |
A3966-10 |
ApexBio |
10 mg |
EUR 108 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
A3966-100 |
ApexBio |
100 mg |
EUR 235 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
A3966-25 |
ApexBio |
25 mg |
EUR 131 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
A3966-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 131 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
A3966-S |
ApexBio |
Evaluation Sample |
EUR 81 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin |
D063-100MG |
TOKU-E |
100 mg |
EUR 1051 |
Doxorubicin |
D063-25MG |
TOKU-E |
25 mg |
EUR 322 |
Erlotinib, Hydrochloride Salt, >99% |
BC026-101 |
GenDepot |
1g |
EUR 273 |
Erlotinib, Hydrochloride Salt, >99% |
BC026-102 |
GenDepot |
2g |
EUR 388 |
Erlotinib, Hydrochloride Salt, >99% |
BC026-105 |
GenDepot |
5g |
EUR 570 |
Adriamycin (Doxorubicin) |
E1KS1208 |
EnoGene |
10mg |
EUR 409 |
Doxorubicin HCl |
20-abx184016 |
Abbexa |
|
|
- Shipped within 1-2 weeks.
|
Doxorubicin 10mM |
TG4120 |
TopoGen |
0.25ml |
EUR 156 |
17-DMAG, Hydrochloride Salt, >98% |
BC024-001 |
GenDepot |
1mg |
EUR 178 |
17-DMAG, Hydrochloride Salt, >98% |
BC024-005 |
GenDepot |
5mg |
EUR 286 |
17-DMAG, Hydrochloride Salt, >98% |
BC024-010 |
GenDepot |
10mg |
EUR 408 |
17-DMAG, Hydrochloride Salt, >98% |
BC024-025 |
GenDepot |
25mg |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-100 |
GenDepot |
100mg |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-101 |
GenDepot |
1g |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-250 |
GenDepot |
250mg |
Ask for price |
OSU-03012, Hydrochloride Salt, >98% |
BC061-005 |
GenDepot |
5mg |
EUR 313 |
OSU-03012, Hydrochloride Salt, >98% |
BC061-025 |
GenDepot |
25mg |
EUR 529 |
Doxorubicin (Adriamycin) HCl |
A1832-10 |
ApexBio |
10 mg |
EUR 125 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin (Adriamycin) HCl |
A1832-100 |
ApexBio |
100 mg |
EUR 467 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin (Adriamycin) HCl |
A1832-25 |
ApexBio |
25 mg |
EUR 189 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin (Adriamycin) HCl |
A1832-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas. |
Doxorubicin HCl, 100mg |
R2531-100mg |
ACTGene |
|
EUR 1300 |
Doxorubicin HCl, 10mg |
R2531-10mg |
ACTGene |
|
EUR 197 |
Anti-EGFR-doxorubicin ADC |
ADC-W-600 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a linker to a doxorubicin |
Anti-CD22-DIBO-doxorubicin ADC |
ADC-W-339 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-CD22 monoclonal antibody conjugated via a DIBO linker to a doxorubicin |
Anti-TNFRSF8 (cAC10)-DIBO-doxorubicin ADC |
ADC-W-406 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cAC10) conjugated via a DIBO linker to a doxorubicin |
Anti-ERBB2 (Trastuzumab)-NGM-doxorubicin ADC |
ADC-W-412 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a NGM linker to adoxorubicin |
Anti-EGFR (cetuximab)-SMCC-Doxorubicin ADC |
ADC-W-504 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody (cetuximab) conjugated via a SMCC linker to Doxorubicin |
Anti-EpCAM (MOC31)-hydrazone-Doxorubicin ADC |
ADC-W-581 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-EPCAM monoclonal antibody (MOC31) conjugated via a hydrazone linker to Doxorubicin |
Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC |
ADC-W-423 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone cBR96) conjugated via a hydrazone linker to adoxorubicin |
Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC |
ADC-W-376 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a doxorubicin |
Bile salt |
BB0225 |
BBI Biotech |
25g |
EUR 79.58 |
- Product category: Biochemicals/Detergents/Surfactants
|
Anti-TNFRSF8 (cCA10)-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC |
ADC-W-353 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cCA10) conjugated via a β-glucuronide linker to a doxorubicin propyloxazoline (DPO) |
Human HeLa (Cervix Adenocarcinoma) Cell Nuclear Extract - Doxorubicin Stimulated |
HCL-2004 |
Alpha Diagnostics |
100ug |
EUR 225 |
Human HeLa (Cervix Adenocarcinoma) Whole Cell Lysate - Doxorubicin Stimulated |
HCL-2010 |
Alpha Diagnostics |
100ug |
EUR 213 |
Stachydrine (hydrochloride) |
C3648-100 |
ApexBio |
100 mg |
EUR 119 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Stachydrine (hydrochloride) |
C3648-1000 |
ApexBio |
1 g |
EUR 467 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Stachydrine (hydrochloride) |
C3648-250 |
ApexBio |
250 mg |
EUR 206 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Stachydrine (hydrochloride) |
C3648-500 |
ApexBio |
500 mg |
EUR 328 |
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits. |
Barnidipine (hydrochloride) |
C3727-100 |
ApexBio |
100 mg |
EUR 203 |
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. |
Barnidipine (hydrochloride) |
C3727-50 |
ApexBio |
50 mg |
EUR 155 |
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. |
MS049 (hydrochloride) |
C3776-10 |
ApexBio |
10 mg |
EUR 200 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-100 |
ApexBio |
100 mg |
EUR 1181 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-25 |
ApexBio |
25 mg |
EUR 382 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-5 |
ApexBio |
5 mg |
EUR 139 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 150 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
MS049 (hydrochloride) |
C3776-50 |
ApexBio |
50 mg |
EUR 653 |
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor. |
Guanabenz (hydrochloride) |
C3786-100 |
ApexBio |
100 mg |
EUR 231 |
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline. |
Guanabenz (hydrochloride) |
C3786-50 |
ApexBio |
50 mg |
EUR 144 |
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline. |
Ulixertinib (hydrochloride) |
C3921-10 |
ApexBio |
10 mg |
EUR 406 |
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1]. |
Ulixertinib (hydrochloride) |
C3921-25 |
ApexBio |
25 mg |
EUR 661 |
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1]. |
Ulixertinib (hydrochloride) |
C3921-5 |
ApexBio |
5 mg |
EUR 250 |
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1]. |
Chlorcyclizine (hydrochloride) |
C3989-100 |
ApexBio |
100 mg |
EUR 118 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Chlorcyclizine (hydrochloride) |
C3989-1000 |
ApexBio |
1 g |
EUR 595 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Chlorcyclizine (hydrochloride) |
C3989-250 |
ApexBio |
250 mg |
EUR 210 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Chlorcyclizine (hydrochloride) |
C3989-500 |
ApexBio |
500 mg |
EUR 357 |
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking. |
Lofexidine (hydrochloride) |
C3990-1000 |
ApexBio |
1 g |
EUR 126 |
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1]. |
Lofexidine (hydrochloride) |
C3990-5.1 |
ApexBio |
10 mM (in 1mL H2O) |
EUR 113 |
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1]. |
Lofexidine (hydrochloride) |
C3990-500 |
ApexBio |
500 mg |
EUR 100 |
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1]. |
Nortriptyline (hydrochloride) |
C4077-100 |
ApexBio |
100 mg |
EUR 163 |
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter. |
Nortriptyline (hydrochloride) |
C4077-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter. |
Nortriptyline (hydrochloride) |
C4077-50 |
ApexBio |
50 mg |
EUR 116 |
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter. |
Imipramine (hydrochloride) |
C4117-5.1 |
ApexBio |
10 mM (in 1mL H2O) |
EUR 113 |
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3]. |
Imipramine (hydrochloride) |
C4117-5000 |
ApexBio |
5 g |
EUR 108 |
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3]. |
Clorgyline (hydrochloride) |
C4137-100 |
ApexBio |
100 mg |
EUR 224 |
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2]. |
Clorgyline (hydrochloride) |
C4137-25 |
ApexBio |
25 mg |
EUR 110 |
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2]. |
Clorgyline (hydrochloride) |
C4137-50 |
ApexBio |
50 mg |
EUR 154 |
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2]. |
Doxepin (hydrochloride) |
C4153-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine. |
Doxepin (hydrochloride) |
C4153-5000 |
ApexBio |
5 g |
EUR 168 |
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine. |
Anhydrochlortetracycline (hydrochloride) |
C4218-1 |
ApexBio |
1 mg |
EUR 132 |
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem. |
Anhydrochlortetracycline (hydrochloride) |
C4218-5 |
ApexBio |
5 mg |
EUR 255 |
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem. |
Anhydrotetracycline (hydrochloride) |
C4291-100 |
ApexBio |
100 mg |
EUR 241 |
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1]. |
Anhydrotetracycline (hydrochloride) |
C4291-25 |
ApexBio |
25 mg |
EUR 123 |
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1]. |
Anhydrotetracycline (hydrochloride) |
C4291-50 |
ApexBio |
50 mg |
EUR 171 |
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1]. |
(±)-Salsolinol (hydrochloride) |
C4364-500 |
ApexBio |
500 mg |
EUR 308 |
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions. |
Midodrine (hydrochloride) |
C4493-100 |
ApexBio |
100 mg |
EUR 113 |
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol. |
Midodrine (hydrochloride) |
C4493-250 |
ApexBio |
250 mg |
EUR 200 |
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol. |
Celiprolol (hydrochloride) |
C4521-10 |
ApexBio |
10 mg |
EUR 254 |
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor. |
Celiprolol (hydrochloride) |
C4521-25 |
ApexBio |
25 mg |
EUR 500 |
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor. |
Celiprolol (hydrochloride) |
C4521-5 |
ApexBio |
5 mg |
EUR 183 |
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor. |
Aceclidine (hydrochloride) |
C4635-1000 |
ApexBio |
1 g |
EUR 328 |
Aceclidine (hydrochloride) |
C4635-500 |
ApexBio |
500 mg |
EUR 206 |
Trimidox (hydrochloride) |
C4714-10 |
ApexBio |
10 mg |
EUR 184 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Trimidox (hydrochloride) |
C4714-25 |
ApexBio |
25 mg |
EUR 370 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Trimidox (hydrochloride) |
C4714-5 |
ApexBio |
5 mg |
EUR 121 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Trimidox (hydrochloride) |
C4714-50 |
ApexBio |
50 mg |
EUR 618 |
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis. |
Cycloguanil (hydrochloride) |
C5763-10 |
ApexBio |
10 mg |
EUR 109 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
Cycloguanil (hydrochloride) |
C5763-25 |
ApexBio |
25 mg |
EUR 163 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
Cycloguanil (hydrochloride) |
C5763-50 |
ApexBio |
50 mg |
EUR 206 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
VU590 (hydrochloride) |
C4778-10 |
ApexBio |
10 mg |
EUR 195 |
VU590 (hydrochloride) |
C4778-25 |
ApexBio |
25 mg |
EUR 389 |
VU590 (hydrochloride) |
C4778-5 |
ApexBio |
5 mg |
EUR 139 |
Bufuralol (hydrochloride) |
C5043-1 |
ApexBio |
1 mg |
EUR 139 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
Bufuralol (hydrochloride) |
C5043-10 |
ApexBio |
10 mg |
EUR 628 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
Bufuralol (hydrochloride) |
C5043-5 |
ApexBio |
5 mg |
EUR 457 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
AN3365 (hydrochloride) |
C5068-10 |
ApexBio |
10 mg |
EUR 328 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
AN3365 (hydrochloride) |
C5068-25 |
ApexBio |
25 mg |
EUR 659 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
AN3365 (hydrochloride) |
C5068-5 |
ApexBio |
5 mg |
EUR 206 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
Calindol (hydrochloride) |
C5329-10 |
ApexBio |
10 mg |
EUR 440 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Calindol (hydrochloride) |
C5329-25 |
ApexBio |
25 mg |
EUR 902 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Calindol (hydrochloride) |
C5329-5 |
ApexBio |
5 mg |
EUR 270 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Kasugamycin (hydrochloride) |
C5503-10000 |
ApexBio |
10 g |
EUR 350 |
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside. |
Kasugamycin (hydrochloride) |
C5503-5000 |
ApexBio |
5 g |
EUR 251 |
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside. |
Ciprofloxacin (hydrochloride) |
C5539-10000 |
ApexBio |
10 g |
EUR 116 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
Ciprofloxacin (hydrochloride) |
C5539-25000 |
ApexBio |
25 g |
EUR 154 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
Ciprofloxacin (hydrochloride) |
C5539-50000 |
ApexBio |
50 g |
EUR 224 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
Fendiline (hydrochloride) |
C5675-5000 |
ApexBio |
5 g |
EUR 122 |
Description: Fendiline is an ?2-adrenergic receptor antagonist and L-type calcium channel blocker [1,2].The ?2 adrenergic receptor is a G protein-coupled receptor (GPCR). Until now, three different ?2-receptor subtypes have been identified: ?2A, ?2B, and ?2C. |
Afuresertib hydrochloride |
B1848-5 |
Biovision |
|
EUR 175 |
Chlorpromazine hydrochloride |
B1992-100 |
Biovision |
|
EUR 120 |
Chlorpromazine hydrochloride |
B1992-500 |
Biovision |
|
EUR 294 |
Triflupromazine hydrochloride |
B1993-100 |
Biovision |
|
EUR 120 |
ZLN024 hydrochloride |
B2034-25 |
Biovision |
|
EUR 588 |
ZLN024 hydrochloride |
B2034-5 |
Biovision |
|
EUR 185 |
Topotecan hydrochloride |
B2050-10 |
Biovision |
|
EUR 131 |
Givinostat hydrochloride |
B2081-25 |
Biovision |
|
EUR 756 |
Givinostat hydrochloride |
B2081-5 |
Biovision |
|
EUR 229 |
Moexipril hydrochloride |
B2134-25 |
Biovision |
|
EUR 294 |
Imidapril hydrochloride |
B2135-25 |
Biovision |
|
EUR 414 |
Imidapril hydrochloride |
B2135-5 |
Biovision |
|
EUR 142 |
Benazepril hydrochloride |
B2138-250 |
Biovision |
|
EUR 294 |
Benazepril hydrochloride |
B2138-50 |
Biovision |
|
EUR 131 |
Dorzolamide hydrochloride |
B2185-10 |
Biovision |
|
EUR 120 |
Dorzolamide hydrochloride |
B2185-50 |
Biovision |
|
EUR 327 |
Eltoprazine hydrochloride |
B2301-25 |
Biovision |
|
EUR 457 |
Eltoprazine hydrochloride |
B2301-5 |
Biovision |
|
EUR 153 |
Papaverine hydrochloride |
B2315-250 |
Biovision |
|
EUR 262 |
Papaverine hydrochloride |
B2315-50 |
Biovision |
|
EUR 120 |
Sarecycline hydrochloride |
B2383-25 |
Biovision |
|
EUR 588 |
Sarecycline hydrochloride |
B2383-5 |
Biovision |
|
EUR 185 |
Sertraline (hydrochloride) |
B2393-10 |
Biovision |
|
EUR 131 |
Sertraline (hydrochloride) |
B2393-50 |
Biovision |
|
EUR 327 |
Migalastat hydrochloride |
B2404-25 |
Biovision |
|
EUR 756 |
Migalastat hydrochloride |
B2404-5 |
Biovision |
|
EUR 229 |
Butenafine hydrochloride |
B2421-250 |
Biovision |
|
EUR 327 |
Butenafine hydrochloride |
B2421-50 |
Biovision |
|
EUR 120 |
Naftifine hydrochloride |
B2422-10 |
Biovision |
|
EUR 131 |
Naftifine hydrochloride |
B2422-50 |
Biovision |
|
EUR 349 |
Rilpivirine hydrochloride |
B2427-25 |
Biovision |
|
EUR 414 |
Rilpivirine hydrochloride |
B2427-5 |
Biovision |
|
EUR 142 |
Tirabrutinib hydrochloride |
B2556-25 |
Biovision |
|
EUR 457 |
Tirabrutinib hydrochloride |
B2556-5 |
Biovision |
|
EUR 153 |
Robenidine hydrochloride |
B2560-1G |
Biovision |
|
EUR 131 |
Robenidine hydrochloride |
B2560-5G |
Biovision |
|
EUR 262 |
Sardomozide Hydrochloride |
B2566-25 |
Biovision |
|
EUR 631 |
Sardomozide Hydrochloride |
B2566-5 |
Biovision |
|
EUR 196 |
Riviciclib hydrochloride |
B2567-1 |
Biovision |
|
EUR 142 |
Riviciclib hydrochloride |
B2567-5 |
Biovision |
|
EUR 414 |
CPTH2 (hydrochloride) |
B2815-1 |
Biovision |
|
EUR 120 |
CPTH2 (hydrochloride) |
B2815-5 |
Biovision |
|
EUR 294 |
Resminostat (hydrochloride) |
B2852-25 |
Biovision |
|
EUR 588 |
Resminostat (hydrochloride) |
B2852-5 |
Biovision |
|
EUR 185 |
Almorexant hydrochloride |
B3241-10 |
ApexBio |
10 mg |
EUR 440 |
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1]. |
Almorexant hydrochloride |
B3241-5 |
ApexBio |
5 mg |
EUR 270 |
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1]. |
Memantine hydrochloride |
B3308-200 |
ApexBio |
200 mg |
EUR 137 |
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1]. |