Familial dilated cardiomyopathy brought on by a novel variant

Subsequent technology sequencing reveals a novel pathogenic variant within the ATMgene

 

Introduction: Ataxia telangiectasia (A-T) is a unusual autosomal recessive multisystemic sickness. Victims with the A-T syndrome present a broad spectrum of sickness phenotypes. The ATM (ataxia telangiectasia mutated) gene, the one causative gene for A-T.

 

Methodology: A affected individual of Persian origin presenting with typical A-T was referred to our genetics center for specialised genetic counseling and testing. Centered next-generation sequencing (NGS) was utilized. Sanger sequencing was used to substantiate the candidate variant. Modeling was carried out using the SWISS-MODEL server.Outcomes: A homozygous stop-gain variant c.829G > T (p.E277*) was found throughout the ATM gene. This variant was confirmed by Sanger sequencing and modeling of native building and truncated building was carried out.

 

Conclusion: Up to now, just a few pathogenic variants of the ATM gene have been reported from the Iranian inhabitants. The discovering has implications in molecular diagnostic for A-T in Iran.

Product not found

Familial dilated cardiomyopathy introduced on by a novel variant throughout the Lamin A/C gene: a case report

Background: Familial dilated cardiomyopathy (FDCM) is generally inherited as an autosomal dominant trait. The Lamin A/C (LMNA) gene variants have been acknowledged to be associated to DCM, conductive system issues, form 2 Emery-Dreifuss muscular dystrophy and numerous different completely different issues. Proper right here, we reported a novel variant throughout the LMNA gene that’s prone to be related to FDCM.

 

Case presentation: A 30-year-old youthful man was hospitalized for chest tightness, extreme fatigue, palpitation and impaired train tolerance. He had scientific traits along with cardiac dilatation, atrial tachyarrhythmia, excessive conductive system issues, and dyskinesia of every increased limbs and the neck. Genetic sequence analysis indicated that the affected individual carried a novel c.1325 T>C heterozygous LMNA gene variant. Catheter ablation and cardiac resynchronization treatment with pacing carry out (CRT-P) have been carried out to take care of the arrhythmia.

 

Conclusion: The variant c.1325 T>C is a novel variant throughout the LMNA gene that has not been beforehand reported. Youthful victims with DCM, conductive system issues and skeletal myopathy should be alert to the potential for LMNA gene variant. Cardiac resynchronization treatment (CRT) is also an inexpensive choice for affected individual carrying a LMNA gene variant with third-degree atrioventricular block even when the left ventricular ejection fraction is preserved with the intention to cease the deterioration of cardiac carry out introduced on by correct ventricular pacing dependency.

Genetic analysis of children with congenital ocular anomalies in three ecological areas of Nepal: a piece II of Nepal pediatric ocular sicknesses analysis

 

Background: Genetic eye sicknesses symbolize a giant and heterogeneous group of childhood ocular morbidity. Specific individual sicknesses may set off numerous structural anomalies and developmental choices. Nepal Pediatric Ocular Sickness Analysis (NPODS) was a population-based epidemiological analysis carried out all through three ecological areas of Nepal to search out out the prevalence and etiology of childhood ocular morbidity and blindness. In Half II of this analysis, genetic analysis was carried out for teenagers who’ve been found to have congenital ocular anomalies.

 

Methodology: It was a cross sectional descriptive analysis. A whole of 10,270 kids all through three completely completely different ecological areas in Nepal (Low lands, hills, and mountains) underwent ocular examinations in NPODS. Out of 374 (3.6%) of children with ocular abnormalities, 30 have been thought-about congenital in nature. Centered genetic analysis, along with genotyping for genes explicit to presenting phenotype, was carried out for 25 kids using serum samples.

 

Outcomes: Out of 25 kids, 18 had important genetic outcomes. Analysis revealed one missense alteration G12411T of Zinc Finger Homeobox 4 (ZFHX4) gene in a single participant amongst 10 with congenital ptosis and one different missense variation T > C P. Y374 C of Signaling Receptor and Transporter Retinol 6 (STRA6) gene in a single participant amongst Three with microphthalmos.

 

Conclusion: The analysis is first of its kind from Nepal and mutant genes have been distinctive to Nepalese Inhabitants. Extra analysis of genetic parts is crucial to increased understand genetic affiliation with ocular sicknesses and conditions. This helps extra in genetic counseling and probably gene treatment to forestall blindness from these conditions.

 

Doxorubicin (hydrochloride)
HY-15142	MedChemExpress	100mg	EUR 147

Doxorubicin hydrochloride
GA4969-100MG	Glentham Life Sciences	100 mg	EUR 181

Doxorubicin hydrochloride
GA4969-10MG	Glentham Life Sciences	10 mg	EUR 78

Doxorubicin hydrochloride
GA4969-25MG	Glentham Life Sciences	25 mg	EUR 98

Doxorubicin hydrochloride
GA4969-50MG	Glentham Life Sciences	50 mg	EUR 126

Doxorubicin Hydrochloride
20-abx076623	Abbexa	EUR 342.00 EUR 787.00	10 mg 50 mg
Shipped within 5-12 working days.

Doxorubicin hydrochloride
TNC00267	ChemNorm	20mg	Ask for price

Doxorubicin hydrochloride USP
D005-10MG	TOKU-E	10 mg	EUR 166

Doxorubicin hydrochloride USP
D005-25MG	TOKU-E	25 mg	EUR 301

Doxorubicin Hydrochloride (Autophagy inducer)
SIH-390-10MG	Stressmarq	10 mg	EUR 193
Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefo Show more
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM)..

Doxorubicin Hydrochloride (Autophagy inducer)
SIH-390-50MG	Stressmarq	50 mg	EUR 529
Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefo Show more
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM)..

Erlotinib, Hydrochloride Salt
1588-100	Biovision		EUR 169

Erlotinib, Hydrochloride Salt
1588-1000	Biovision		EUR 398

Doxorubicin
ADC-P-013	Creative Biolabs	unit	Ask for price

Doxorubicin
HY-15142A	MedChemExpress	100mg	EUR 215

Doxorubicin
abx188695-1g	Abbexa	1 g	EUR 467
Shipped within 1-2 weeks.

Doxorubicin
A3966-10	ApexBio	10 mg	EUR 108
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-100	ApexBio	100 mg	EUR 235
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-25	ApexBio	25 mg	EUR 131
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 131
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-S	ApexBio	Evaluation Sample	EUR 81
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
D063-100MG	TOKU-E	100 mg	EUR 1051

Doxorubicin
D063-25MG	TOKU-E	25 mg	EUR 322

Erlotinib, Hydrochloride Salt, >99%
BC026-101	GenDepot	1g	EUR 273

Erlotinib, Hydrochloride Salt, >99%
BC026-102	GenDepot	2g	EUR 388

Erlotinib, Hydrochloride Salt, >99%
BC026-105	GenDepot	5g	EUR 570

Adriamycin (Doxorubicin)
E1KS1208	EnoGene	10mg	EUR 409

Doxorubicin HCl
20-abx184016	Abbexa	EUR 746.00 EUR 1483.00	1 g 5 g
Shipped within 1-2 weeks.

Doxorubicin 10mM
TG4120	TopoGen	0.25ml	EUR 156

17-DMAG, Hydrochloride Salt, >98%
BC024-001	GenDepot	1mg	EUR 178

17-DMAG, Hydrochloride Salt, >98%
BC024-005	GenDepot	5mg	EUR 286

17-DMAG, Hydrochloride Salt, >98%
BC024-010	GenDepot	10mg	EUR 408

17-DMAG, Hydrochloride Salt, >98%
BC024-025	GenDepot	25mg	Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-100	GenDepot	100mg	Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-101	GenDepot	1g	Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-250	GenDepot	250mg	Ask for price

OSU-03012, Hydrochloride Salt, >98%
BC061-005	GenDepot	5mg	EUR 313

OSU-03012, Hydrochloride Salt, >98%
BC061-025	GenDepot	25mg	EUR 529

Doxorubicin (Adriamycin) HCl
A1832-10	ApexBio	10 mg	EUR 125
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl
A1832-100	ApexBio	100 mg	EUR 467
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl
A1832-25	ApexBio	25 mg	EUR 189
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl
A1832-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin HCl, 100mg
R2531-100mg	ACTGene		EUR 1300

Doxorubicin HCl, 10mg
R2531-10mg	ACTGene		EUR 197

Anti-EGFR-doxorubicin ADC
ADC-W-600	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody conjugated via a linker to a doxorubicin

Anti-CD22-DIBO-doxorubicin ADC
ADC-W-339	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-CD22 monoclonal antibody conjugated via a DIBO linker to a doxorubicin

Anti-TNFRSF8 (cAC10)-DIBO-doxorubicin ADC
ADC-W-406	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cAC10) conjugated via a DIBO linker to a doxorubicin

Anti-ERBB2 (Trastuzumab)-NGM-doxorubicin ADC
ADC-W-412	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a NGM linker to adoxorubicin

Anti-EGFR (cetuximab)-SMCC-Doxorubicin ADC
ADC-W-504	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-EGFR monoclonal antibody (cetuximab) conjugated via a SMCC linker to Doxorubicin

Anti-EpCAM (MOC31)-hydrazone-Doxorubicin ADC
ADC-W-581	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-EPCAM monoclonal antibody (MOC31) conjugated via a hydrazone linker to Doxorubicin

Anti-FUT3 (clone cBR96)-hydrazone-doxorubicin ADC
ADC-W-423	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-FUT3 monoclonal antibody (clone cBR96) conjugated via a hydrazone linker to adoxorubicin

Anti-CD70 (clone h1F6)-β-glucuronide-doxorubicin ADC
ADC-W-376	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-CD70 monoclonal antibody (clone h1F6) conjugated via a β-glucuronide linker to a doxorubicin

Bile salt
BB0225	Bio Basic	25g	EUR 79.58
Product category: Biochemicals/Detergents/Surfactants

Anti-TNFRSF8 (cCA10)-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC
ADC-W-353	Creative Biolabs	1mg	Ask for price
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (cCA10) conjugated via a β-glucuronide linker to a doxorubicin propyloxazoline (DPO)

Human HeLa (Cervix Adenocarcinoma) Cell Nuclear Extract - Doxorubicin Stimulated
HCL-2004	Alpha Diagnostics	100ug	EUR 225

Human HeLa (Cervix Adenocarcinoma) Whole Cell Lysate - Doxorubicin Stimulated
HCL-2010	Alpha Diagnostics	100ug	EUR 213

Stachydrine (hydrochloride)
C3648-100	ApexBio	100 mg	EUR 119
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)
C3648-1000	ApexBio	1 g	EUR 467
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)
C3648-250	ApexBio	250 mg	EUR 206
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Stachydrine (hydrochloride)
C3648-500	ApexBio	500 mg	EUR 328
Description: Stachydrine is an anti-metastatic agent.Stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of C. Leonurus, and many other Asian plants and fruits.

Barnidipine (hydrochloride)
C3727-100	ApexBio	100 mg	EUR 203
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

Barnidipine (hydrochloride)
C3727-50	ApexBio	50 mg	EUR 155
Description: Barnidipine is a calcium-channel blocker.A calcium channel, an ion channel which displays selective permeability to calcium ions, is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels.

MS049 (hydrochloride)
C3776-10	ApexBio	10 mg	EUR 200
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-100	ApexBio	100 mg	EUR 1181
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-25	ApexBio	25 mg	EUR 382
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-5	ApexBio	5 mg	EUR 139
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 150
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

MS049 (hydrochloride)
C3776-50	ApexBio	50 mg	EUR 653
Description: IC50: 34 nM for PRMT4; 43 nM for PRMT6 MS049 is a dual PRMT4 and PRMT6 inhibitor.

Guanabenz (hydrochloride)
C3786-100	ApexBio	100 mg	EUR 231
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Guanabenz (hydrochloride)
C3786-50	ApexBio	50 mg	EUR 144
Description: Guanabenz is an orally active ?2-adrenoceptor agonist with hypotensive effects [1]. The ?2 adrenergic receptors belong to a family of G protein-coupled receptor (GPCR), mediate many physiological actions of the endogenous catecholamines adrenaline and noradrenaline.

Ulixertinib (hydrochloride)
C3921-10	ApexBio	10 mg	EUR 406
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)
C3921-25	ApexBio	25 mg	EUR 661
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Ulixertinib (hydrochloride)
C3921-5	ApexBio	5 mg	EUR 250
Description: Ulixertinib, also named as BVD-523, is a novel and reversible inhibitor of ERK1/2. Ulixertinib potently and selectively inhibits the activity of ERK1 and ERK2 kinases in a reversible, ATP-competitive fashion [1].

Chlorcyclizine (hydrochloride)
C3989-100	ApexBio	100 mg	EUR 118
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)
C3989-1000	ApexBio	1 g	EUR 595
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)
C3989-250	ApexBio	250 mg	EUR 210
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Chlorcyclizine (hydrochloride)
C3989-500	ApexBio	500 mg	EUR 357
Description: Chlorcyclizine is a phenylpiperazine antagonist for histamine H1 receptor [1]. The histamine has been involved in modulating many physiological functions of the hypothalamus, such as arousal state, feeding, locomotor activity, and drinking.

Lofexidine (hydrochloride)
C3990-1000	ApexBio	1 g	EUR 126
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)
C3990-5.1	ApexBio	10 mM (in 1mL H2O)	EUR 113
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Lofexidine (hydrochloride)
C3990-500	ApexBio	500 mg	EUR 100
Description: Lofexidine is a ?2-Receptor agonist for opioid detoxification. Lofexidine shows a strong affinity for the ?2A-receptor subtype [1].

Nortriptyline (hydrochloride)
C4077-100	ApexBio	100 mg	EUR 163
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)
C4077-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Nortriptyline (hydrochloride)
C4077-50	ApexBio	50 mg	EUR 116
Description: Ki: 3.4 nM: blocks the norepinephrine transporter.Ki: 161 nM: inhibits the serotonin transporter.

Imipramine (hydrochloride)
C4117-5.1	ApexBio	10 mM (in 1mL H2O)	EUR 113
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Imipramine (hydrochloride)
C4117-5000	ApexBio	5 g	EUR 108
Description: Imipramine (hydrochloride) is a tricyclic antidepressant and is mainly used in the treatment of major depression and enuresis [1]. Antidepressants are antagonists of many neurotransmitter receptors in human brain [3].

Clorgyline (hydrochloride)
C4137-100	ApexBio	100 mg	EUR 224
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)
C4137-25	ApexBio	25 mg	EUR 110
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Clorgyline (hydrochloride)
C4137-50	ApexBio	50 mg	EUR 154
Description: Clorgyline (hydrochloride) is an irreversible, potent and selective monoamine oxidase (MAO) A inhibitor with Ki values of 0.054 and 58 ?M and IC50 values of 0.0012 and 1.9 ?M for MAO-A and MAO-B, respectively [1][2].

Doxepin (hydrochloride)
C4153-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 113
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Doxepin (hydrochloride)
C4153-5000	ApexBio	5 g	EUR 168
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Anhydrochlortetracycline (hydrochloride)
C4218-1	ApexBio	1 mg	EUR 132
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrochlortetracycline (hydrochloride)
C4218-5	ApexBio	5 mg	EUR 255
Description: Anhydrochlortetracycline was produced by the acid degradation of chlortetracycline. Anhydrochlortetracycline only have a fraction of the antibacterial activity of chlortetracycline. Anhydrochlortetracycline strongly inhibited the growth of Streptomyces aureofaciem.

Anhydrotetracycline (hydrochloride)
C4291-100	ApexBio	100 mg	EUR 241
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)
C4291-25	ApexBio	25 mg	EUR 123
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

Anhydrotetracycline (hydrochloride)
C4291-50	ApexBio	50 mg	EUR 171
Description: Anhydrotetracycline (hydrochloride) (ATC) is a powerful effector for the tetracycline repressor (TetR) and reverse tetracycline repressor (revTetR) systems [1].

(±)-Salsolinol (hydrochloride)
C4364-500	ApexBio	500 mg	EUR 308
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions.

Midodrine (hydrochloride)
C4493-100	ApexBio	100 mg	EUR 113
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Midodrine (hydrochloride)
C4493-250	ApexBio	250 mg	EUR 200
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol.

Celiprolol (hydrochloride)
C4521-10	ApexBio	10 mg	EUR 254
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)
C4521-25	ApexBio	25 mg	EUR 500
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Celiprolol (hydrochloride)
C4521-5	ApexBio	5 mg	EUR 183
Description: Celiprolol is a ?1 adrenergic receptor antagonist and ?2 adrenergic receptor partial agonist.?2 adrenergic receptor agonists, also known as adrenergic ?2 receptor agonists, are a class of drugs acting on the ?2 adrenergic receptor.

Aceclidine (hydrochloride)
C4635-1000	ApexBio	1 g	EUR 328

Aceclidine (hydrochloride)
C4635-500	ApexBio	500 mg	EUR 206

Trimidox (hydrochloride)
C4714-10	ApexBio	10 mg	EUR 184
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)
C4714-25	ApexBio	25 mg	EUR 370
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)
C4714-5	ApexBio	5 mg	EUR 121
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Trimidox (hydrochloride)
C4714-50	ApexBio	50 mg	EUR 618
Description: Trimidox (hydrochloride) is a specific ribonucleotide reductase inhibitor [1][2][3]. Ribonucleotide reductase is the rate-limiting enzyme for de novo DNA synthesis.

Cycloguanil (hydrochloride)
C5763-10	ApexBio	10 mg	EUR 109
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)
C5763-25	ApexBio	25 mg	EUR 163
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

Cycloguanil (hydrochloride)
C5763-50	ApexBio	50 mg	EUR 206
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid.

VU590 (hydrochloride)
C4778-10	ApexBio	10 mg	EUR 195

VU590 (hydrochloride)
C4778-25	ApexBio	25 mg	EUR 389

VU590 (hydrochloride)
C4778-5	ApexBio	5 mg	EUR 139

Bufuralol (hydrochloride)
C5043-1	ApexBio	1 mg	EUR 139
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)
C5043-10	ApexBio	10 mg	EUR 628
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

Bufuralol (hydrochloride)
C5043-5	ApexBio	5 mg	EUR 457
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing.

AN3365 (hydrochloride)
C5068-10	ApexBio	10 mg	EUR 328
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)
C5068-25	ApexBio	25 mg	EUR 659
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

AN3365 (hydrochloride)
C5068-5	ApexBio	5 mg	EUR 206
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family.

Calindol (hydrochloride)
C5329-10	ApexBio	10 mg	EUR 440
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)
C5329-25	ApexBio	25 mg	EUR 902
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Calindol (hydrochloride)
C5329-5	ApexBio	5 mg	EUR 270
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis.

Kasugamycin (hydrochloride)
C5503-10000	ApexBio	10 g	EUR 350
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Kasugamycin (hydrochloride)
C5503-5000	ApexBio	5 g	EUR 251
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside.

Ciprofloxacin (hydrochloride)
C5539-10000	ApexBio	10 g	EUR 116
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)
C5539-25000	ApexBio	25 g	EUR 154
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Ciprofloxacin (hydrochloride)
C5539-50000	ApexBio	50 g	EUR 224
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1].

Fendiline (hydrochloride)
C5675-5000	ApexBio	5 g	EUR 122
Description: Fendiline is an ?2-adrenergic receptor antagonist and L-type calcium channel blocker [1,2].The ?2 adrenergic receptor is a G protein-coupled receptor (GPCR). Until now, three different ?2-receptor subtypes have been identified: ?2A, ?2B, and ?2C.

Afuresertib hydrochloride
B1848-5	Biovision		EUR 175

Chlorpromazine hydrochloride
B1992-100	Biovision		EUR 120

Chlorpromazine hydrochloride
B1992-500	Biovision		EUR 294

Triflupromazine hydrochloride
B1993-100	Biovision		EUR 120

ZLN024 hydrochloride
B2034-25	Biovision		EUR 588

ZLN024 hydrochloride
B2034-5	Biovision		EUR 185

Topotecan hydrochloride
B2050-10	Biovision		EUR 131

Givinostat hydrochloride
B2081-25	Biovision		EUR 756

Givinostat hydrochloride
B2081-5	Biovision		EUR 229

Moexipril hydrochloride
B2134-25	Biovision		EUR 294

Imidapril hydrochloride
B2135-25	Biovision		EUR 414

Imidapril hydrochloride
B2135-5	Biovision		EUR 142

Benazepril hydrochloride
B2138-250	Biovision		EUR 294

Benazepril hydrochloride
B2138-50	Biovision		EUR 131

Dorzolamide hydrochloride
B2185-10	Biovision		EUR 120

Dorzolamide hydrochloride
B2185-50	Biovision		EUR 327

Eltoprazine hydrochloride
B2301-25	Biovision		EUR 457

Eltoprazine hydrochloride
B2301-5	Biovision		EUR 153

Papaverine hydrochloride
B2315-250	Biovision		EUR 262

Papaverine hydrochloride
B2315-50	Biovision		EUR 120

Sarecycline hydrochloride
B2383-25	Biovision		EUR 588

Sarecycline hydrochloride
B2383-5	Biovision		EUR 185

Sertraline (hydrochloride)
B2393-10	Biovision		EUR 131

Sertraline (hydrochloride)
B2393-50	Biovision		EUR 327

Migalastat hydrochloride
B2404-25	Biovision		EUR 756

Migalastat hydrochloride
B2404-5	Biovision		EUR 229

Butenafine hydrochloride
B2421-250	Biovision		EUR 327

Butenafine hydrochloride
B2421-50	Biovision		EUR 120

Naftifine hydrochloride
B2422-10	Biovision		EUR 131

Naftifine hydrochloride
B2422-50	Biovision		EUR 349

Rilpivirine hydrochloride
B2427-25	Biovision		EUR 414

Rilpivirine hydrochloride
B2427-5	Biovision		EUR 142

Tirabrutinib hydrochloride
B2556-25	Biovision		EUR 457

Tirabrutinib hydrochloride
B2556-5	Biovision		EUR 153

Robenidine hydrochloride
B2560-1G	Biovision		EUR 131

Robenidine hydrochloride
B2560-5G	Biovision		EUR 262

Sardomozide Hydrochloride
B2566-25	Biovision		EUR 631

Sardomozide Hydrochloride
B2566-5	Biovision		EUR 196

Riviciclib hydrochloride
B2567-1	Biovision		EUR 142

Riviciclib hydrochloride
B2567-5	Biovision		EUR 414

CPTH2 (hydrochloride)
B2815-1	Biovision		EUR 120

CPTH2 (hydrochloride)
B2815-5	Biovision		EUR 294

Resminostat (hydrochloride)
B2852-25	Biovision		EUR 588

Resminostat (hydrochloride)
B2852-5	Biovision		EUR 185

Almorexant hydrochloride
B3241-10	ApexBio	10 mg	EUR 440
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Almorexant hydrochloride
B3241-5	ApexBio	5 mg	EUR 270
Description: Almorexant is an antagonist of Orexin 1 receptor (OX1R) and Orexin 2 receptor (OX2R) with Kd values of 1.3nM and 0.17nM, respectively [1].

Memantine hydrochloride
B3308-200	ApexBio	200 mg	EUR 137
Description: Memantine hydrochloride is an antagonist of NMDA receptor with IC50 values of 0.93?M, 0.82?M and 0.47?M for NRIa/NR2A, NRIa/NR2B and NRIa/NR2D, respectively [1].