Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype-specific antibodies.

Muscarinic ACh receptors mediate complicated and clinically vital results within the striatum. To higher perceive the roles of the completely different muscarinic receptor subtypes (m1-m4), now we have decided the mobile and subcellular distribution of the m1-m4 receptor proteins within the rat neostriatum utilizing subtype-specific antibodies and avidin-biotin-peroxidase immunocytochemistry for mild and electron microscopy. m1 receptor protein is expressed in 78% of neurons and is enriched in spiny dendrites and at postsynaptic densities. A small variety of m1-immunoreactive axon terminals had been noticed, all forming asymmetrical synapses.

About 2.5% of striatal neurons specific m2 receptor protein with response product evident, by mild microscopy in scattered giant oval neurons with enfolded nuclei and lengthy aspiny dendrites. By electron microscopy, m2 immunocytochemistry labeled somata, aspiny dendrites, and lots of axon terminals. Most axon terminals containing m2 make symmetrical synapses with somata, and dendritic shafts and spines. As well as, many m2-immunoreactive axon terminals fashioned asymmetrical synapses with spines or dendrites. m3 receptor protein was not evident in somata by mild microscopy however was current in a definite inhabitants of small-caliber spiny dendrites in addition to in axon terminals forming asymmetrical synapses with spines.

m4 receptor protein was heterogeneously distributed within the neostriatum and localized to 44% of striatal cells. m4-positive neurons had the ultrastructural options of medium spiny neurons with response product notably concentrated in spines, typically at postsynaptic densities. Axon terminals containing m4 kind asymmetrical synapses, primarily with spines. These findings point out that the muscarinic receptor proteins happen in distinct populations of striatal neurons; that the receptor proteins focus postsynaptically at synapses, together with many thought of to be noncholinergic; that m2 is the predominant muscarinic autoreceptor within the striatum; and that every receptor subtype could also be a presynaptic heteroceptor within the striatum modulating extrinsic striatal afferents.

The amyloid speculation of Alzheimer’s illness at 25 years.

Regardless of persevering with debate concerning the amyloid β-protein (or Aβ speculation, new strains of proof from laboratories and clinics worldwide assist the idea that an imbalance between manufacturing and clearance of Aβ42 and associated Aβ peptides is a really early, typically initiating think about Alzheimer’s illness (AD). Affirmation that presenilin is the catalytic web site of γ-secretase has offered a linchpin: all dominant mutations inflicting early-onset AD happen both within the substrate (amyloid precursor protein, APP) or the protease (presenilin) of the response that generates Aβ.

Duplication of the wild-type APP gene in Down’s syndrome results in Aβ deposits within the teenagers, adopted by microgliosis, astrocytosis, and neurofibrillary tangles typical of AD Apolipoprotein E4, which predisposes to AD in>> 40% of instances, has been discovered to impair Aβ clearance from the mind. Soluble oligomers of Aβ42 remoted from AD sufferers’ brains can lower synapse quantity, inhibit long-term potentiation, and improve long-term synaptic despair in rodent hippocampus, and injecting them into wholesome rats impairs reminiscence. The human oligomers additionally induce hyperphosphorylation of tau at AD-relevant epitopes and trigger neuritic dystrophy in cultured neurons.

Crossing human APP with human tau transgenic mice enhances tau-positive neurotoxicity. In people, new research present that low cerebrospinal fluid (CSF) Aβ42 and amyloid-PET positivity precede different AD manifestations by a few years. Most significantly, latest trials of three completely different Aβ antibodies (solanezumab, crenezumab, and aducanumab) have steered a slowing of cognitive decline in submit hoc analyses of gentle AD topics. Though many elements contribute to AD pathogenesis, Aβ dyshomeostasis has emerged as essentially the most extensively validated and compelling therapeutic goal.

Particular proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

Apoptosis is a morphologically and biochemically distinct type of cell dying that happens below a wide range of physiological and pathological situations. Within the current research, the proteolytic cleavage of poly(ADP-ribose) polymerase (pADPRp) throughout the course of chemotherapy-induced apoptosis was examined. Remedy of HL-60 human leukemia cells with the topoisomerase II-directed anticancer agent etoposide resulted in morphological adjustments attribute of apoptosis. Endonucleolytic degradation of DNA to generate nucleosomal fragments occurred concurrently.

Western blotting with epitope-specific monoclonal and polyclonal antibodies revealed that these attribute apoptotic adjustments had been accompanied by early, quantitative cleavage of the M(r) 116,000 pADPRp polypeptide to an M(r) roughly 25,000 fragment containing the amino-terminal DNA-binding area of pADPRp and an M(r) roughly 85,000 fragment containing the automodification and catalytic domains. Exercise blotting revealed that the M(r) roughly 85,000 fragment retained basal pADPRp exercise however was not activated by exogenous nicked DNA. Comparable cleavage of pADPRp was noticed after publicity of HL-60 cells to a wide range of chemotherapeutic brokers together with cis-diaminedichloroplatinum(II), colcemid, 1-beta-D-arabinofuranosylcytosine, and methotrexate; to gamma-irradiation

or to the protein synthesis inhibitors puromycin or cycloheximide. Comparable adjustments had been noticed in MDA-MB-468 human breast most cancers cells handled with trifluorothymidine or 5-fluoro-2′-deoxyuridine and in gamma-irradiated or glucocorticoid-treated rat thymocytes present process apoptosis. Remedy with a number of compounds (tosyl-L-lysine chloromethyl ketone, tosyl-L-phenylalanine chloromethyl ketone, N-ethylmaleimide, iodoacetamide) prevented each the proteolytic cleavage of pADPRp and the internucleosomal fragmentation of DNA. The outcomes recommend that proteolytic cleavage of pADPRp, along with being an early marker of chemotherapy-induced apoptosis, may replicate extra widespread proteolysis that may be a vital biochemical occasion early throughout the means of physiological cell dying.

Myosin Heavy Chain Monoclonal Antibody
ABM40058-003ml	Abbkine	0.03ml	EUR 158
Description: A monoclonal antibody for detection of Myosin Heavy Chain from Human, Mouse, Rat, Fruit Fly, Nematode. This Myosin Heavy Chain antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Myosin Heavy Chain Monoclonal Antibody
ABM40058-01ml	Abbkine	0.1ml	EUR 289
Description: A monoclonal antibody for detection of Myosin Heavy Chain from Human, Mouse, Rat, Fruit Fly, Nematode. This Myosin Heavy Chain antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Myosin Heavy Chain Monoclonal Antibody
ABM40058-02ml	Abbkine	0.2ml	EUR 414
Description: A monoclonal antibody for detection of Myosin Heavy Chain from Human, Mouse, Rat, Fruit Fly, Nematode. This Myosin Heavy Chain antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Myosin Heavy Chain (Mhc) Antibody
abx235172-100ug	Abbexa	100 ug	EUR 551

Anti-Myosin Heavy Chain antibody
STJ96960	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Myosin Heavy Chain.

Myosin Heavy Chain Monoclonal Antibody
EM1058-100ul	ELK Biotech	100ul	EUR 279
Description: A Mouse Monoclonal antibody against Myosin Heavy Chain from Human/ Mouse/ Rat/ Fruit Fly/ Nematode. This antibody is tested and validated for IHC, IF

Myosin Heavy Chain Monoclonal Antibody
EM1058-50ul	ELK Biotech	50ul	EUR 207
Description: A Mouse Monoclonal antibody against Myosin Heavy Chain from Human/ Mouse/ Rat/ Fruit Fly/ Nematode. This antibody is tested and validated for IHC, IF

Myosin Heavy Chain protein
30-1187	Fitzgerald	100 ug	EUR 839
Description: Purified native Human Myosin Heavy Chain protein

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx130543	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx126210	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx113944	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Myosin Heavy Chain 2 (MYH2) Antibody
20-abx113946	Abbexa	EUR 732.00 EUR 398.00	150 ul 50 ul

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx103932	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 4 (MYH4) Antibody
20-abx103933	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 4 (MYH4) Antibody
20-abx103934	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 2 (MYH2) Antibody
20-abx104340	Abbexa	EUR 411.00 EUR 133.00 EUR 1135.00 EUR 551.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 16 (MYH16) Antibody
20-abx102273	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 4 (MYH4) Antibody
20-abx014616	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx001267	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

Myosin Heavy Chain 2 (MYH2) Antibody
20-abx002613	Abbexa	EUR 411.00 EUR 592.00	100 ul 200 ul

Anti-MYH14/Myosin Heavy Chain Antibody
A04528	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal MYH14/Myosin Heavy Chain Antibody. Validated in WB and tested in Human.

Myosin Heavy Chain 4 (MYH4) Antibody
20-abx323087	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Myosin Heavy Chain 15 (MYH15) Antibody
20-abx323947	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Myosin Heavy Chain 2 (MYH2) Antibody
20-abx217005	Abbexa	EUR 425.00 EUR 342.00	100 ug 50 ug

Myosin Heavy Chain 15 (MYH15) Antibody
abx217027-100ug	Abbexa	100 ug	EUR 439

Myosin Heavy Chain 11 (MYH11) Antibody
abx238026-100ug	Abbexa	100 ug	EUR 481

Myosin Heavy Chain 11 (MYH11) Antibody
abx238027-100ug	Abbexa	100 ug	EUR 509

Myosin Heavy Chain 11 (MYH11) Antibody
abx238028-100ug	Abbexa	100 ug	EUR 509

Myosin Heavy Chain 11 (MYH11) Antibody
abx238029-100ug	Abbexa	100 ug	EUR 551

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx214496	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx214949	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx177672	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 2 (MYH2) Antibody
20-abx177673	Abbexa	EUR 398.00 EUR 133.00 EUR 1107.00 EUR 537.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Myosin Heavy Chain 2 (MYH2) Antibody
20-abx177674	Abbexa	EUR 1135.00 EUR 551.00	1 mg 200 ug

Myosin Heavy Chain 4 (MYH4) Antibody
20-abx177675	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx173675	Abbexa	EUR 857.00 EUR 439.00	1 mg 200 ug

Myosin Heavy Chain 2 (MYH2) Antibody
20-abx173676	Abbexa	EUR 787.00 EUR 411.00	1 mg 200 ug

Myosin Heavy Chain 4 (MYH4) Antibody
20-abx173678	Abbexa	EUR 342.00 EUR 857.00 EUR 439.00 EUR 154.00 EUR 258.00	100 ug 1 mg 200 ug 20 ug 50 ug

Monoclonal antibody for Myosin heavy chain
SMC-258D	Stressmarq	0.1ml	EUR 314
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is not conjugated.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A390	Stressmarq	0.1ml	EUR 361
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 390.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A488	Stressmarq	0.1ml	EUR 360
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 488.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A565	Stressmarq	0.1ml	EUR 360
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 565.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A594	Stressmarq	0.1ml	EUR 360
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 594.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A633	Stressmarq	0.1ml	EUR 360
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 633.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A655	Stressmarq	0.1ml	EUR 360
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 655.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A680	Stressmarq	0.1ml	EUR 360
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 680.

Monoclonal antibody for Myosin heavy chain
SMC-258D-A700	Stressmarq	0.1ml	EUR 360
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with ATTO 700.

Monoclonal antibody for Myosin heavy chain
SMC-258D-ALP	Stressmarq	0.1ml	EUR 355
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Alkaline Phosphatase.

Monoclonal antibody for Myosin heavy chain
SMC-258D-APC	Stressmarq	0.1ml	EUR 359
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with APC.

Monoclonal antibody for Myosin heavy chain
SMC-258D-APCCY7	Stressmarq	0.1ml	EUR 432
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with APC/Cy7.

Monoclonal antibody for Myosin heavy chain
SMC-258D-BI	Stressmarq	0.1ml	EUR 357
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Biotin.

Monoclonal antibody for Myosin heavy chain
SMC-258D-DY350	Stressmarq	0.1ml	EUR 436
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Dylight 350.

Monoclonal antibody for Myosin heavy chain
SMC-258D-DY405	Stressmarq	0.1ml	EUR 412
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Dylight 405.

Monoclonal antibody for Myosin heavy chain
SMC-258D-DY488	Stressmarq	0.1ml	EUR 393
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Dylight 488.

Monoclonal antibody for Myosin heavy chain
SMC-258D-DY594	Stressmarq	0.1ml	EUR 397
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Dylight 594.

Monoclonal antibody for Myosin heavy chain
SMC-258D-DY633	Stressmarq	0.1ml	EUR 387
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Dylight 633.

Monoclonal antibody for Myosin heavy chain
SMC-258D-FITC	Stressmarq	0.1ml	EUR 353
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with FITC.

Monoclonal antibody for Myosin heavy chain
SMC-258D-HRP	Stressmarq	0.1ml	EUR 349
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with HRP.

Monoclonal antibody for Myosin heavy chain
SMC-258D-P594	Stressmarq	0.1ml	EUR 367
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with PE/ATTO 594.

Monoclonal antibody for Myosin heavy chain
SMC-258D-PCP	Stressmarq	0.1ml	EUR 359
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with PerCP.

Monoclonal antibody for Myosin heavy chain
SMC-258D-RPE	Stressmarq	0.1ml	EUR 358
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with RPE.

Monoclonal antibody for Myosin heavy chain
SMC-258D-STR	Stressmarq	0.1ml	EUR 359
Description: A monoclonal antibody from clone 11C2 against Human | Mouse Myosin heavy chain. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthesized peptide derived from human Myosin Heavy Chain. The antibody is tested and validated for IHC, ICC/IF assays with the following recommended dilutions: IHC (1:100), ICC/IF (1:100). This MAb for Myosin heavy chain is conjugated with Streptavidin.

Myosin Heavy Chain Mouse Monoclonal Antibody
38013-100ul	SAB	100ul	EUR 252

Myosin Heavy Chain Mouse Monoclonal Antibody
38013-50ul	SAB	50ul	EUR 187

Myosin Heavy Chain 4 (MYH4) Antibody
abx330335-100ul	Abbexa	100 ul	EUR 425

Myosin Heavy Chain 4 (MYH4) Antibody
20-abx334199	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Myosin Heavy Chain 11 (MYH11) Antibody
20-abx334295	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Myosin heavy chain recombinant monoclonal antibody
A5558	Bimake	100ul X 3	EUR 595
Description: A recombinant monoclonal antibody from rabbit against human Myosin heavy chain for WB, IHC,ELISA

anti-Myosin Heavy Chain (11C2)
LF-MA20351	Abfrontier	100 ug	EUR 354
Description: Mouse monoclonal to Myosin Heavy Chain

anti-heavy chain cardiac Myosin
YF-PA24193	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to heavy chain cardiac Myosin

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNCA0893-250	Biotium	250uL	EUR 383
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), APC conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNCAP0893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNCAP0893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC810893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF680R conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC810893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF680R conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNCB0893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), Biotin conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNCB0893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), Biotin conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC550893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF555 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC550893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF555 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC430893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF543 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC430893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF543 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC470893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF647 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC470893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF647 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC880893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF488A conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC880893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF488A conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC940893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF594 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC940893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF594 conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNCP0893-250	Biotium	250uL	EUR 383
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), PerCP conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC040893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF405S conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC040893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF405S conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC050893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF405M conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC050893-500	Biotium	500uL	EUR 544
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF405M conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNCR0893-250	Biotium	250uL	EUR 383
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), RPE conjugate, Concentration: 0.1mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNUB0893-100	Biotium	100uL	EUR 209
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), Concentration: 0.2mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNUB0893-500	Biotium	500uL	EUR 458
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), Concentration: 0.2mg/mL

Myosin Smooth Muscle Heavy Chain(SMMS-1) Antibody
BNC680893-100	Biotium	100uL	EUR 199
Description: Primary antibody against Myosin, Smooth Muscle Heavy Chain(SMMS-1), CF568 conjugate, Concentration: 0.1mg/mL

Artificial Abeta oligomers of the identical dimension gave equivalent punctate binding, which was extremely selective for explicit neurons. Picture evaluation by confocal double-label immunofluorescence established that >90% of the punctate oligomer binding websites colocalized with the synaptic marker PSD-95 (postsynaptic density protein 95). Synaptic binding was accompanied by ectopic induction of Arc, a synaptic immediate-early gene, the overexpression of which has been linked to dysfunctional studying. Outcomes recommend the speculation that concentrating on and practical disruption of explicit synapses by Abeta oligomers might present a molecular foundation for the precise lack of reminiscence operate in early AD.